Adult neural stem cells express glucose transporters GLUT1 and GLUT3 and regulate GLUT3 expression

被引：40
|
作者：
Maurer, Martin H. [1 ]
Geomor, H. Kenny [1 ]
Buergers, Heinrich F. [1 ]
Schelshorn, Dominik W. [1 ]
Kuschinsky, Wolfgang [1 ]
机构：
[1] Univ Heidelberg, Dept Physiol & Pathophysiol, D-69120 Heidelberg, Germany
来源：
FEBS LETTERS | 2006年 / 580卷 / 18期
关键词：
neural stem cell; neurosphere; glucose transporter; GLUT1; GLUT3; rat brain subventricular zone;
D O I：
10.1016/j.febslet.2006.07.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the brain, glucose is transported by GLUT1 across the blood-brain barrier and into astrocytes, and by GLUT3 into neurons. In the present study, the expression of GLUT1 and GLUT3 mRNA and protein was determined in adult neural stem cells cultured from the subventricular zone of rats. Both mRNAs and proteins were coexpressed, GLUT1 protein being 5-fold higher than GLUT3. Stress induced by hypoxia and/or hyperglycemia increased the expression of GLUT1 and GLUT3 mRNA and of GLUT3 protein. It is concluded that adult neural stem cells can transport glucose by GLUT1 and GLUT3 and can regulate their glucose transporter densities. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：4430 / 4434
页数：5
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