A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B

被引：35

作者：

Namba, K ^{[1
]}

Jun, HS ^{[1
]}

Kishi, Y ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 25期

关键词：

D O I：

10.1021/ja047826b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple device consisting of two ion-exchange columns, two alumina-based filters, and a pump (Figure 1) was assembled to form the C8-C14 polycyclic ring system present in the halichondrin B class of marine natural products. The effectiveness of this device was tested for three substrates. In each case, the desired polycyclic ketal 3, 5, or 7 was obtained almost quantitatively in a single operation. Copyright © 2004 American Chemical Society.

引用

页码：7770 / 7771

页数：2

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