How does DNA methylation repress transcription?

被引：450
作者：
Kass, SU
Pruss, D
Wolffe, AP
机构：
[1] Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
来源：
TRENDS IN GENETICS | 1997年 / 13卷 / 11期
关键词：
D O I：
10.1016/S0168-9525(97)01268-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA methylation has an essential regulatory function in mammalian development, serving to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data implicate transcriptional repressors specific for methylated DNA and chromatin assembly in this global control of gene activity. The assembly of specialized nucleosomal structures on methylated DNA helps to explain the capacity of methylated DNA segments to silence transcription more effectively than conventional chromatin, Specialized nucleosomes also provide a potential molecular mechanism for the stable propagation of DNA methylation-dependent transcriptional silencing through cell division.
引用
收藏
页码：444 / 449
页数：6
相关论文
共 55 条
[1]   Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression [J].
Alland, L ;
Muhle, R ;
Hou, H ;
Potes, J ;
Chin, L ;
SchreiberAgus, N ;
DePinho, RA .
NATURE, 1997, 387 (6628) :49-55
[2]   SPECIFIC PROTECTION OF METHYLATED CPGS IN MAMMALIAN NUCLEI [J].
ANTEQUERA, F ;
MACLEOD, D ;
BIRD, AP .
CELL, 1989, 58 (03) :509-517
[3]   5-METHYLCYTOSINE IS LOCALIZED IN NUCLEOSOMES THAT CONTAIN HISTONE H-1 [J].
BALL, DJ ;
GROSS, DS ;
GARRARD, WT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18) :5490-5494
[4]   GENE NUMBER, NOISE-REDUCTION AND BIOLOGICAL COMPLEXITY [J].
BIRD, AP .
TRENDS IN GENETICS, 1995, 11 (03) :94-100
[5]   REPRESSION OF GENES BY DNA METHYLATION DEPENDS ON CPG DENSITY AND PROMOTER STRENGTH - EVIDENCE FOR INVOLVEMENT OF A METHYL-CPG BINDING-PROTEIN [J].
BOYES, J ;
BIRD, A .
EMBO JOURNAL, 1992, 11 (01) :327-333
[6]   Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation [J].
Brownell, JE ;
Zhou, JX ;
Ranalli, T ;
Kobayashi, R ;
Edmondson, DG ;
Roth, SY ;
Allis, CD .
CELL, 1996, 84 (06) :843-851
[7]   CHROMATIN STRUCTURE IS REQUIRED TO BLOCK TRANSCRIPTION OF THE METHYLATED HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE [J].
BUSCHHAUSEN, G ;
WITTIG, B ;
GRAESSMANN, M ;
GRAESSMANN, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1177-1181
[8]   BINDING OF HISTONE H1 TO DNA IS INDIFFERENT TO METHYLATION AT CPG SEQUENCES [J].
CAMPOY, FJ ;
MEEHAN, RR ;
MCKAY, S ;
NIXON, J ;
BIRD, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (44) :26473-26481
[9]   STRUCTURE OF CHROMATIN AT DEOXYRIBONUCLEIC-ACID REPLICATION FORKS - NUCLEASE HYPERSENSITIVITY RESULTS FROM BOTH PRENUCLEOSOMAL DEOXYRIBONUCLEIC-ACID AND AN IMMATURE CHROMATIN STRUCTURE [J].
CUSICK, ME ;
LEE, KS ;
DEPAMPHILIS, ML ;
WASSARMAN, PM .
BIOCHEMISTRY, 1983, 22 (16) :3873-3884
[10]  
FELSENFELD G, 1982, COLD SPRING HARB SYM, V47, P577
123456