Targeting Metabotropic Glutamate Receptors as a New Strategy Against Levodopa-Induced Dyskinesia in Parkinson's Disease?

被引：12
作者：
Picconi, Barbara [1 ]
Calabresi, Paolo [1 ,2 ]
机构：
[1] IRCCS, Fdn Santa Lucia, Rome, Italy
[2] Univ Perugia, Osped S Maria della Misericordia, Neurol Clin, I-06156 Perugia, Italy
来源：
MOVEMENT DISORDERS | 2014年 / 29卷 / 06期
关键词：
Parkinson's disease; mGluR5; dyskinesia; levodopa therapy; experimental animal models; DOPA-INDUCED DYSKINESIA; ALLOSTERIC MODULATORS; SYNAPTIC PLASTICITY; MGLUR5; ANTAGONIST; RAT MODEL; STRIATUM; TRANSMISSION; MECHANISMS; ANXIETY; AFQ056;
D O I：
10.1002/mds.25851
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Levodopa-induced dyskinesias (LIDs) represent one major motor disability of Parkinson's disease (PD) therapy. Thus, research effort is still devoted to finding agents that may improve parkinsonism and concomitantly reduce or avoid dyskinesia. Rodent and nonhuman primate models provide useful tools to study the molecular and neuronal bases of LIDs. Among the various strategies investigated recently, the use of drugs targeting metabotropic glutamate receptors has received large attention. In particular, use of antagonists of the subtype 5 of metabotropic glutamate receptors revealed promising preclinical and clinical results. (c) 2014 International Parkinson and Movement Disorder Society
引用
收藏
页码：715 / 719
页数：5
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