Meta-Analysis of Infectious Agents and Depression

被引：66

作者：

Wang, Xiao ^{[1
,2
]}

Zhang, Liang ^{[1
,2
,3
]}

Lei, Yang ^{[1
,2
,3
]}

Liu, Xia ^{[1
,2
,3
]}

Zhou, Xinyu ^{[1
,2
,3
]}

Liu, Yiyun ^{[1
,2
,3
]}

Wang, Mingju ^{[1
,2
,3
]}

Yang, Liu ^{[1
,2
]}

Zhang, Lujun ^{[1
,2
]}

Fan, Songhua ^{[1
,2
,3
]}

Xie, Peng ^{[1
,2
,3
]}

机构：

[1] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China

[2] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China

[3] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

基金：

中国国家自然科学基金;

关键词：

BORNA-DISEASE VIRUS; EPSTEIN-BARR-VIRUS; TOXOPLASMA-GONDII; SERUM ANTIBODIES; CELLULAR-IMMUNITY; SCHIZOPHRENIA; DISORDERS; MEASLES; ANXIETY; BRAINS;

D O I：

10.1038/srep04530

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO, and the Cochrane Library was conducted up to May 2013, and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus, and Chlamydophila trachomatis.

引用

页数：10

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