Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen

被引：6

作者：

Auer, Matthias K. ^{[1
]}

Hellweg, Rainer ^{[2
]}

Briken, Peer ^{[3
]}

Stalla, Guenter K. ^{[1
]}

T'Sjoen, Guy ^{[4
]}

Fuss, Johannes ^{[3
]}

机构：

[1] Max Planck Inst Psychiat, Endocrinol Diabetol & Internal Med, D-80804 Munich, Germany

[2] Univ Med Berlin, Dept Psychiat, Campus Charite Mitte, D-10117 Berlin, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Ctr Psychosocial Med, Inst Sex Res & Forens Psychiat, D-20246 Hamburg, Germany

[4] Ghent Univ Hosp, Dept Endocrinol, B-9000 Ghent, Belgium

来源：

BIOLOGY OF SEX DIFFERENCES | 2016年 / 7卷

关键词：

Transsexualism; Estradiol; Sex steroids; Testosterone; Brain-derived neurotropic factor; BDNF; Gender dysphoria; Brain morphology; Platelets; SEX HORMONE-TREATMENT; HUMAN PLATELETS; GENDER; PLASMA; ANDROGEN; RELEASE; TRANSSEXUALISM; PROGESTERONE; RECEPTOR; THERAPY;

D O I：

10.1186/s13293-015-0055-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain morphology significantly differs between the sexes. It has been shown before that some of these differences are attributable to the sex-specific hormonal milieu. Brain-derived neurotrophic factor (BDNF) is involved in myriads of neuroplastic processes and shows a sexual dimorphism. Transsexual persons may serve as a model to study sex steroid-mediated effects on brain plasticity. We have recently demonstrated that serum levels of BDNF are reduced in transwomen following 12 months of cross-sex hormone treatment. We now wanted to look at the effects of testosterone treatment on BDNF in transmen. In contrast to our initial hypothesis, BDNF levels did not significantly change, despite dramatic changes in the sex-hormonal milieu. Our data indicate that testosterone does not seem to play a major role in the regulation of BDNF in females.

引用

页数：6

共 49 条

[1] SIMULTANEOUS RADIOIMMUNOASSAY OF PLASMA FSH, LH, PROGESTERONE, 17-HYDROXYPROGESTERONE, AND ESTRADIOL-17BETA DURING MENSTRUAL-CYCLE [J].

ABRAHAM, GE ;

SWERDLOFF, RS ;

HOPPER, K ;

ODELL, WD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 34 (02) :312-+

[2] Psychopathological Profiles in Transsexuals and the Challenge of Their Special Status among the Sexes [J].

Auer, Matthias K. ;

Hoehne, Nina ;

Bazarra-Castro, Maria Angeles ;

Pfister, Hildegard ;

Fuss, Johannes ;

Stalla, Guenter K. ;

Sievers, Caroline ;

Ising, Marcus .

PLOS ONE, 2013, 8 (10)

[3] Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up [J].

Auer, Matthias K. ;

Fuss, Johannes ;

Stalla, Guenter K. ;

Athanasoulia, Anastasia P. .

FERTILITY AND STERILITY, 2013, 100 (04) :1103-1110

[4] Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor [J].

Begliuomini, S. ;

Casarosa, E. ;

Pluchino, N. ;

Lenzi, E. ;

Centofanti, M. ;

Freschi, L. ;

Pieri, M. ;

Genazzani, A. D. ;

Luisi, S. ;

Genazzani, Andrea R. .

HUMAN REPRODUCTION, 2007, 22 (04) :995-1002

[5] Brain-derived neurotrophic factor [J].

Binder, DK ;

Scharfman, HE .

GROWTH FACTORS, 2004, 22 (03) :123-131

[6] BDNF val66 met allele is associated with reduced hippocampal volume in healthy subjects [J].

Bueller, JA ;

Aftab, M ;

Sen, S ;

Gomez-Hassan, D ;

Burmeister, M ;

Zubieta, JK .

BIOLOGICAL PSYCHIATRY, 2006, 59 (09) :812-815

[7] Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men [J].

Butkiewicz, Anna M. ;

Kemona, Halina ;

Dymicka-Piekarska, Violetta ;

Matowicka-Karna, Joanna ;

Radziwon, Piotr ;

Lipska, Alina .

THROMBOSIS RESEARCH, 2006, 118 (02) :199-204

[8] Cortical activation during mental rotation in male-to-female and female-to-male transsexuals under hormonal treatment [J].

Carrillo, Beatriz ;

Gomez-Gil, Esther ;

Rametti, Giuseppina ;

Junque, Carme ;

Gomez, Angel ;

Karadi, Kazmer ;

Segovia, Santiago ;

Guillamon, Antonio .

PSYCHONEUROENDOCRINOLOGY, 2010, 35 (08) :1213-1222

[9] Effects of androgen deprivation on brain function in prostate cancer patients - a prospective observational cohort analysis [J].

Chao, Herta H. ;

Uchio, Edward ;

Zhang, Sheng ;

Hu, Sien ;

Bednarski, Sarah R. ;

Luo, Xi ;

Rose, Michal ;

Concato, John ;

Li, Chiang-shan R. .

BMC CANCER, 2012, 12

[10] Transsexual patients' psychiatric comorbidity and positive effect of cross-sex hormonal treatment on mental health: Results from a longitudinal study [J].

Colizzi, Marco ;

Costa, Rosalia ;

Todarello, Orlando .

PSYCHONEUROENDOCRINOLOGY, 2014, 39 :65-73

← 1 2 3 4 5 →