Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability

被引:35
作者
Kaewbumrung, Sermwut [1 ]
Panichayupakaranant, Pharkphoom [1 ,2 ]
机构
[1] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90112, Songkhla, Thailand
[2] Prince Songkla Univ, Fac Pharmaceut Sci, Phytomed & Pharmaceut Biotechnol Res Ctr, Hat Yai 90112, Songkhla, Thailand
关键词
Plumbago indica; Plumbago rosea; plumbagin; elliptinone; biplumbagin; naphthoquinone;
D O I
10.1080/14786419.2013.879585
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The extraction studies and a one-step purification of the crude extract of Plumbago indica using silica-gel vacuum chromatography provided a plumbagin derivative-rich P. indica root extract (PPE). The PPE was standardised to contain total plumbagin derivatives not less than 13% w/w. Antibacterial activities of the standardised PPE and three naphthoquinones, plumbagin, elliptinone and 3,3-biplumbagin, against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis were evaluated by using the microdilution assay. The bactericidal activities of the PPE against these bacteria were much stronger than those of elliptinone and 3,3-biplumbagin and almost equal to those of plumbagin. Stability of the PPE was determined under various conditions through a period of four months. The PPE was stable over a period of four months when stored as a dried powder but only in a well-closed container protected from light under 4 +/- 2 degrees C.
引用
收藏
页码:835 / 837
页数:3
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