Dendritic core-shell systems as soft drug delivery nanocarriers

被引：51

作者：

Lukowiak, Maike C. ^{[1
]}

Thota, Bala N. S. ^{[1
]}

Haag, Rainer ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

BIOTECHNOLOGY ADVANCES | 2015年 / 33卷 / 06期

基金：

美国国家科学基金会;

关键词：

Unimolecular micelles; Core-shell; Core-multishell; Hyperbranched; Dendritic; Polymeric amphiphiles; Encapsulation; Aggregation; Drug delivery; Targeting; BLOCK-COPOLYMER MICELLES; DERIVATIZED HYPERBRANCHED POLYGLYCEROLS; CHAIN WALKING POLYMERIZATION; BREAST-CANCER CELLS; ONE-POT SYNTHESIS; UNIMOLECULAR MICELLES; BIOMEDICAL APPLICATIONS; IN-VITRO; POLYETHYLENE AMPHIPHILES; ANTICANCER DRUGS;

D O I：

10.1016/j.biotechadv.2015.03.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Unimolecular micelles are covalently bound molecular architectures and therefore highly stable which makes them particularly attractive for drug delivery. Accordingly, many reports in the literature emphasize the importance of these molecular architectures for nanomedicine. This conceptual review will present some of the recent advances in the application of these dendritic core-shell systems for drug delivery. Unimolecular micelles based on hyperbranched and dendritic cores will be discussed and sorted by the nature of their core and structure. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：1327 / 1341

页数：15

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