Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

被引：31

作者：

Jorgensen, Hanne Skou ^{[1
,2
]}

David, Karel ^{[1
,3
]}

Salam, Syazrah ^{[4
,5
,6
]}

Evenepoel, Pieter ^{[1
,7
]}

机构：

[1] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Nephrol & Renal Transplantat Res Grp, Leuven, Belgium

[2] Aarhus Univ, Inst Clin Med, Aarhus, Denmark

[3] Katholieke Univ Leuven, Dept Chron Dis & Metab, Lab Clin & Expt Endocrinol, Leuven, Belgium

[4] Sheffield Teaching Hosp Natl Hlth Serv Fdn Trust, Sheffield Kidney Inst, Sheffield, S Yorkshire, England

[5] Univ Sheffield, Acad Unit Bone Metab, Sch Med, Sheffield, S Yorkshire, England

[6] Univ Sheffield, Mellanby Ctr Bone Res 3, Sch Med, Sheffield, S Yorkshire, England

[7] Univ Hosp Leuven, Dept Nephrol & Renal Transplantat, Leuven, Belgium

来源：

CALCIFIED TISSUE INTERNATIONAL | 2021年 / 108卷 / 04期

关键词：

Bone density; Chronic kidney disease— mineral and bone disorder; Chronic renal insufficiency; Fracture; Kidney transplantation; Osteoporosis;

D O I：

10.1007/s00223-020-00786-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.

引用

页码：496 / 511

页数：16

共 184 条

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