Functional Role of microRNAs in Regulating Cardiomyocyte Death

被引：33

作者：

Kansakar, Urna ^{[1
]}

Varzideh, Fahimeh ^{[1
]}

Mone, Pasquale ^{[1
]}

Jankauskas, Stanislovas S. ^{[1
,2
]}

Santulli, Gaetano ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Med Cardiol, Wilf Family Cardiovasc Res Inst, Einstein Inst Aging Res,Inst Neuroimmunol & Infla, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Fleischer Inst Diabet & Metab FIDAM, Einstein Mt Sinai Diabet Res Ctr ES DRC, Dept Mol Pharmacol, New York, NY 10461 USA

来源：

CELLS | 2022年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

cell death; cardiomyocytes; ischemia; reperfusion; myocardial infarction; heart failure; autophagy; apoptosis; necrosis; non-coding RNA; HYPOXIA/REOXYGENATION-INDUCED INJURY; HYPOXIA-INDUCED APOPTOSIS; PROGRAMMED CELL-DEATH; CIRCULATING MICRORNAS; MOLECULAR-MECHANISMS; PROGNOSTIC VALUE; H9C2; CELLS; ISCHEMIA/REPERFUSION INJURY; PROTECTS CARDIOMYOCYTES; MYOCARDIAL-INFARCTION;

D O I：

10.3390/cells11060983

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

引用

页数：13

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