Pyrazine- and pyridine-substituted prop-2-yn-1-ols, but-3-yn-2-ols, and but-3-yn-2-ones - purification, stability, and handling revised

被引：3

作者：

Schindler, Claudia ^{[1
]}

Schulzke, Carola ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Biochem, 4 Felix Hausdorff Str, D-17487 Greifswald, Germany

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 11-12期

基金：

欧洲研究理事会;

关键词：

alkynylpyrazines; alkynylpyridines; alcohol oxidation; purification; Sonogashira cross-coupling reactions; stability; MOLYBDENUM COFACTOR; SONOGASHIRA REACTION; HETEROARYL HALIDES; EFFICIENT; ALKYNES; MODEL; COMPLEX; ENZYMES;

D O I：

10.1007/s10593-016-1811-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short series of alkynyl-substituted pyrazine and pyridine derivatives was synthesized by the palladium-catalyzed Sonogashira cross-coupling reactions between aryl halides and alkynes. All the products are either white solids or colorless liquids, which is partly in contrast to previous reports. After purification, a color change or intense darkening was observed, in some cases starting almost immediately. Both, the nature of the heteroaromatic ring and the substituents of the alkyne moiety affect their stability. Herein details of synthesis, characterization, and, most importantly, purification and handling are reported.

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页码：1008 / 1013

页数：6

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