Radiation therapy for choroidal melanoma

被引:227
作者
Finger, PT
机构
[1] NYU, SCH MED,N SHORE UNIV HLTH SYST,DEPT OPHTHALMOL, DIV OCULAR TUMOR & ORBITAL DIS, NEW YORK, NY USA
[2] NYU, SCH MED,N SHORE UNIV HLTH SYST,DEPT RADIOL, DIV OCULAR TUMOR & ORBITAL DIS, NEW YORK, NY USA
[3] ST VINCENTS MED CTR, DEPT OPHTHALMOL, NEW YORK, NY USA
[4] ST VINCENTS MED CTR, DEPT RADIAT ONCOL, NEW YORK, NY USA
关键词
charged-particle radiotherapy; choroidal melanoma; enucleation; metastatic disease; plaque radiotherapy;
D O I
10.1016/S0039-6257(97)00088-X
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Radiotherapy offers patients with malignant melanoma of the choroid an eye and a vision sparing alternative to enucleation. The most commonly used forms of radiotherapy are ophthalmic plaque brachytherapy and charged-particle (external beam) radiotherapy. Unfortunately, after all forms of radiotherapy for choroidal melanoma many patients experience sight-limiting side effects, and an average of 16.3% of patients treated with radiotherapy subsequently require enucleation because of tumor regrowth or uncontrollable neovascular glaucoma. The severity, location, and incidence of radiation-induced complications are related to the type of radiation used, its method of delivery, amount of radiation delivered to normal ocular structures, the size and location of the tumor, as well as its response to irradiation. Current research is directed toward developing methods to reduce the amount of radiation delivered to normal structures, e.g., adding heat to radiotherapy. The true viability and metastatic potential of irradiated uveal melanoma cells has not been established, although clinical studies have reported local control of choroidal melanoma in 81-100% (mean = 92.8%) of cases. The purpose of this review is to present the world's experience with radiotherapy for choroidal melanoma, information that will contribute to patient education and informed consent. (C) 1997 by Elsevier Science Inc. All rights reserved.
引用
收藏
页码:215 / 232
页数:18
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