Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition

被引：245

作者：

Canna, Scott W. ^{[1
,5
]}

Girard, Charlotte ^{[2
]}

Malle, Louise ^{[1
]}

de Jesus, Adriana ^{[1
,6
]}

Romberg, Neil ^{[3
]}

Kelsen, Judith ^{[3
]}

Surrey, Lea F. ^{[3
]}

Russo, Pierre ^{[3
]}

Sleight, Andrew ^{[4
]}

Schiffrin, Eduardo ^{[4
]}

Gabay, Cem ^{[2
]}

Goldbach-Mansky, Raphaela ^{[1
,6
]}

Behrens, Edward M. ^{[3
]}

机构：

[1] Natl Inst Arthrit & Musculoskeletal & Skin Dis, Intramural Res Program, Bethesda, MD 20892 USA

[2] Univ Hosp Geneva, Div Rheumatol, Dept Internal Med Specialties, Geneva, Switzerland

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[4] AB2Bio Ltd, Lausanne, Switzerland

[5] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[6] IRP Natl Inst Allergy & Infect Dis, Bethesda, MD USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2017年 / 139卷 / 05期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

JUVENILE IDIOPATHIC ARTHRITIS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; INTERFERON-GAMMA; AUTOINFLAMMATION; MUTATION;

D O I：

10.1016/j.jaci.2016.10.022

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：1698 / 1701

页数：5

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