What can progeroid syndrome tell us about human aging?

被引：133
作者：
Kipling, D
Davis, T
Ostler, EL
Faragher, RGA
机构：
[1] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England
[2] Cardiff Univ, Sch Med, Dept Pathol, Cardiff CF14 4XN, S Glam, Wales
来源：
SCIENCE | 2004年 / 305卷 / 5689期
关键词：
D O I：
10.1126/science.1102587
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.
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页码：1426 / 1431
页数：6
相关论文
共 66 条
[1]   Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells [J].
Baird, DM ;
Davis, T ;
Rowson, J ;
Jones, CJ ;
Kipling, D .
HUMAN MOLECULAR GENETICS, 2004, 13 (14) :1515-1524
[2]   Can we say that senescent cells cause ageing? [J].
Bird, J ;
Ostler, EL ;
Faragher, RGA .
EXPERIMENTAL GERONTOLOGY, 2003, 38 (11-12) :1319-1326
[3]   Extension of life-span by introduction of telomerase into normal human cells [J].
Bodnar, AG ;
Ouellette, M ;
Frolkis, M ;
Holt, SE ;
Chiu, CP ;
Morin, GB ;
Harley, CB ;
Shay, JW ;
Lichtsteiner, S ;
Wright, WE .
SCIENCE, 1998, 279 (5349) :349-352
[4]   Mechanism of telomerase induction during T cell activation [J].
Bodnar, AG ;
Kim, NW ;
Effros, RB ;
Chiu, CP .
EXPERIMENTAL CELL RESEARCH, 1996, 228 (01) :58-64
[5]   Direct evidence from siRNA-directed "knock down" that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation [J].
Bond, J ;
Jones, C ;
Haughton, M ;
DeMicco, C ;
Kipling, D ;
Wynford-Thomas, D .
EXPERIMENTAL CELL RESEARCH, 2004, 292 (01) :151-156
[6]   Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [J].
Bridger, JM ;
Kill, IR .
EXPERIMENTAL GERONTOLOGY, 2004, 39 (05) :717-724
[7]   Models of growth hormone and IGF-1 deficiency: Applications to studies of aging processes and life-span determination [J].
Carter, CS ;
Ramsey, MM ;
Ingram, RL ;
Cashion, AB ;
Cefalu, WT ;
Wang, ZQ ;
Sonntag, WE .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2002, 57 (05) :B177-B188
[8]   TELOMERE LENGTH AND REPLICATIVE AGING IN HUMAN VASCULAR TISSUES [J].
CHANG, E ;
HARLEY, CB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11190-11194
[9]   Essential role of limiting telomeres in the pathogenesis of Werner syndrome [J].
Chang, S ;
Multani, AS ;
Cabrera, NG ;
Naylor, ML ;
Laud, P ;
Lombard, D ;
Pathak, S ;
Guarente, L ;
DePinho, RA .
NATURE GENETICS, 2004, 36 (08) :877-882
[10]   COST OF MATING IN DROSOPHILA-MELANOGASTER FEMALES IS MEDIATED BY MALE ACCESSORY-GLAND PRODUCTS [J].
CHAPMAN, T ;
LIDDLE, LF ;
KALB, JM ;
WOLFNER, MF ;
PARTRIDGE, L .
NATURE, 1995, 373 (6511) :241-244
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