Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

被引：40

作者：

Kendall, MAF ^{[1
]}

Quinlan, NJ

Thorpe, SJ

Ainsworth, RW

Bellhouse, BJ

机构：

[1] Univ Oxford, Dept Engn Sci, Oxford OX1 2JD, England

[2] Natl Univ Irelend, Dept Mech & Biomed Engn, Galway, Ireland

来源：

EXPERIMENTS IN FLUIDS | 2004年 / 37卷 / 01期

关键词：

D O I：

10.1007/s00348-004-0792-4

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).

引用

页码：128 / 136

页数：9

共 19 条

[11]

KENDALL MAF, 2001, ASME BIOENG C SNOWB

[12] A DNA vaccine encoding a peptide mimic of Streptococcus pneumoniae serotype 4 capsular polysaccharide induces specific anti-carbohydrate antibodies in Balb/c mice [J].