Cytogenetics and molecular cytogenetics in multiple myeloma

被引：48

作者：

Liebisch, Peter ^{[1
]}

Doehner, Hartmut ^{[1
]}

机构：

[1] Univ Hosp Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 11期

关键词：

multiple myeloma; paraproteinemias; chromosome banding; fluorescence in situ hybridization (FISH); comparative genomic hybridization (CGH); IgH translocation; hyperdiploidy;

D O I：

10.1016/j.ejca.2005.12.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) is characterized by frequent and complex genomic abnormalities that not only essentially contribute to the pathogenesis of this disease but also reflect its prognostic heterogeneity. There is evidence for two more or less mutually exclusive oncogenic pathways in the early development of clonal plasma cell disorders. Approximately half the tumours are non-hyperdiploid and carry translocations of the immunoglobulin heavy-chain (IgH) locus and various oncogenes, for example Cyclin D1, Cyclin D3, and FGFR3. The remaining hyperdiploid tumours exhibit recurrent trisomies - typically of chromosomes 5, 7, 9, 11, 15, 19, and 21 - but infrequently exhibit IgH translocations. While some chromosomal aberrations, such as deletion of chromosome arm 13q, deliver independent prognostic information that is already utilized for risk stratification within clinical trials, the prognostic significance of most other genetic aberrations in MM is undetermined. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1520 / 1529

页数：10

共 105 条

[1]

Aalto Y, 1999, GENE CHROMOSOME CANC, V25, P104

[2] Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance [J].

Ackermann, J ;

Meidlinger, P ;

Zojer, N ;

Gisslinger, H ;

Ludwig, H ;

Huber, H ;

Drach, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 103 (04) :1161-1163

[3] A novel three-color, clone-specific fluorescence in situ hybridization procedure for monoclonal gammopathies [J].

Ahmann, GJ ;

Jalal, SM ;

Juneau, AL ;

Christensen, ER ;

Hanson, CA ;

Dewald, GW ;

Greipp, PR .

CANCER GENETICS AND CYTOGENETICS, 1998, 101 (01) :7-11

[4]

Avet-Loiseau H, 1999, CANCER RES, V59, P4546

[5] Detection of nonrandom chromosomal changes in multiple myeloma by comparative genomic hybridization [J].

Avet-Loiseau, H ;

Bataille, R .

BLOOD, 1998, 92 (08) :2997-2998

[6] P53 deletion is not a frequent event in multiple myeloma [J].

Avet-Loiseau, H ;

Li, JY ;

Godon, C ;

Morineau, N ;

Daviet, A ;

Harousseau, JL ;

Facon, T ;

Bataille, R .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 106 (03) :717-719

[7] Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants [J].

Avet-Loiseau, H ;

Garand, R ;

Lodé, L ;

Harousseau, JL ;

Bataille, R .

BLOOD, 2003, 101 (04) :1570-1571

[8] Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation [J].

Avet-Loiseau, H ;

Facon, T ;

Grosbois, B ;

Magrangeas, F ;

Rapp, MJ ;

Harousseau, JL ;

Minvielle, S ;

Bataille, R .

BLOOD, 2002, 99 (06) :2185-2191

[9]

Avet-Loiseau H, 1998, CANCER RES, V58, P5640

[10]

Avet-Loiseau H, 1999, GENE CHROMOSOME CANC, V24, P9, DOI 10.1002/(SICI)1098-2264(199901)24:1<9::AID-GCC2>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →