TALL-CELL VARIANT PAPILLARY THYROID CARCINOMA ARISING FROM STRUMA OVARII

被引:7
作者
Karagkounis, Georgios [1 ]
Chute, Deborah J. [2 ]
Nasr, Christian E. [3 ]
Berber, Eren [4 ]
机构
[1] Cleveland Clin Fdn, Dept Gen Surg, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Dept Diabet Endocrinol & Metab, Cleveland, OH 44195 USA
[4] Cleveland Clin Fdn, Dept Endocrine Surg, Cleveland, OH 44195 USA
关键词
FOLLICULAR VARIANT; CANCER; BRAF; MUTATION; MANAGEMENT;
D O I
10.4158/EP13205.CR
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To present a case of tall-cell variant (TCV) papillary thyroid carcinoma (PTC) arising from Struma ovarii (SO) and to discuss special considerations in the management of this patient. Methods: The clinical presentation and relevant pathologic features of a patient with PTC-TCV developing from SO are described, and a concise review of literature regarding this topic is also presented. Results: A 36-year-old woman with a history of stable right ovarian dermoid cyst presented with amenorrhea and was found to have a significantly enlarged right ovary with multiple cysts. Following laparoscopic cystectomy, pathology revealed mature cystic teratoma (SO) with associated PTC-TCV. Based on this finding, she underwent right salpingo-oophorectomy, right pelvic lymph node dissection, and partial omentectomy. Pathology was negative for extra-ovarian disease, and her tumor was staged as pT1pN0M0. Total thyroidectomy was performed in preparation for radioactive iodine (RAI) therapy. A diagnostic iodine-131 (I-131) scan showed residual uptake in the neck with faint uptake in the lower left quadrant of the abdomen and was followed by therapy with 90 mCi of I-131. The patient had an unremarkable course with no clinical or biochemical evidence of disease recurrence to date. Conclusions: This is to our knowledge the first reported case of TCV-PTC arising from SO. The presence of this aggressive variant of PTC factored into our decision to proceed with thyroidectomy and I-131 ablation, despite the lack of conclusive evidence in the literature. Recent discoveries on the natural history of thyroid-derived TCVPTC were critical in choosing the appropriate management for this patient's disease.
引用
收藏
页码:E24 / E27
页数:4
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