Gold-catalyzed tandem cycloisomerization-hydroalkoxylation of homopropargylic alcohols

被引：192
作者：
Belting, Volker [1 ]
Krause, Norbert [1 ]
机构：
[1] Univ Dortmund, D-44221 Dortmund, Germany
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 20期
关键词：
D O I：
10.1021/ol061751u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The tandem cycloisomerization-hydroalkoxylation of various homopropargylic alcohols in the presence of an alcohol and a dual catalyst system, consisting of a gold precatalyst and a Bronsted acid, provides an efficient route to tetrahydrofuranyl ethers under mild reaction conditions. The reaction can be carried out in various solvents, including alcohol, with both terminal and internal alkynes as the substrate.
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页码：4489 / 4492
页数：4
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