The Genetic Complexity of Prostate Cancer

被引：13

作者：

Comperat, Eva ^{[1
,2
,3
]}

Wasinger, Gabriel ^{[3
]}

Oszwald, Andre ^{[3
]}

Kain, Renate ^{[3
]}

Cancel-Tassin, Geraldine ^{[1
]}

Cussenot, Olivier ^{[1
,4
]}

机构：

[1] Sorbonne Univ, CeRePP, GRC5 Predict Onco Urol, F-75020 Paris, France

[2] Sorbonne Univ, Dept Pathol, Hop Tenon, F-75020 Paris, France

[3] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria

[4] Sorbonne Univ, Dept Urol, Hop Tenon, F-75020 Paris, France

来源：

GENES | 2020年 / 11卷 / 12期

关键词：

prostate cancer; germline mutations; somatic mutations; PTEN; TMPRSS2; ERG; androgen receptors; ANDROGEN RECEPTOR; CONSENSUS CONFERENCE; DNA-REPAIR; MUTATIONS; SPOP; RISK; EXPRESSION; GERMLINE; SURVIVAL; FUSION;

D O I：

10.3390/genes11121396

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge.

引用

页码：1 / 12

页数：12

共 67 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade [J].

Abida, Wassim ;

Cheng, Michael L. ;

Armenia, Joshua ;

Middha, Sumit ;

Autio, Karen A. ;

Vargas, Hebert Alberto ;

Rathkopf, Dana ;

Morris, Michael J. ;

Danila, Daniel C. ;

Slovin, Susan F. ;

Carbone, Emily ;

Barnett, Ethan S. ;

Hullings, Melanie ;

Hechtman, Jaclyn F. ;

Zehir, Ahmet ;

Shia, Jinru ;

Jonsson, Philip ;

Stadler, Zsofia K. ;

Srinivasan, Preethi ;

Laudone, Vincent P. ;

Reuter, Victor ;

Wolchok, Jedd D. ;

Socci, Nicholas D. ;

Taylor, Barry S. ;

Berger, Michael F. ;

Kantoff, Philip W. ;

Sawyers, Charles L. ;

Schultz, Nikolaus ;

Solit, David B. ;

Gopalan, Anuradha ;

Scher, Howard I. .

JAMA ONCOLOGY, 2019, 5 (04) :471-478

[3] Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants [J].

An, Jian ;

Wang, Chenji ;

Deng, Yibin ;

Yu, Long ;

Huang, Haojie .

CELL REPORTS, 2014, 6 (04) :657-669

[4] Synthetic lethal therapies for cancer: what's next after PARP inhibitors? [J].

Ashworth, Alan ;

Lord, Christopher J. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (09) :564-576

[5] Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer [J].

Attard, G. ;

Clark, J. ;

Ambroisine, L. ;

Fisher, G. ;

Kovacs, G. ;

Flohr, P. ;

Berney, D. ;

Foster, C. S. ;

Fletcher, A. ;

Gerald, W. L. ;

Moller, H. ;

Reuter, V. ;

De Bono, J. S. ;

Scardino, P. ;

Cuzick, J. ;

Cooper, C. S. .

ONCOGENE, 2008, 27 (03) :253-263

[6] Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer [J].

Azad, Arun A. ;

Volik, Stanislav V. ;

Wyatt, Alexander W. ;

Haegert, Anne ;

Le Bihan, Stephane ;

Bell, Robert H. ;

Anderson, Shawn A. ;

McConeghy, Brian ;

Shukin, Robert ;

Bazov, Jenny ;

Youngren, Jack ;

Paris, Pamela ;

Thomas, George ;

Small, Eric J. ;

Wang, Yuzhuo ;

Gleave, Martin E. ;

Collins, Colin C. ;

Chi, Kim N. .

CLINICAL CANCER RESEARCH, 2015, 21 (10) :2315-2324

[7] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[8] Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress [J].

Bassi, C. ;

Ho, J. ;

Srikumar, T. ;

Dowling, R. J. O. ;

Gorrini, C. ;

Miller, S. J. ;

Mak, T. W. ;

Neel, B. G. ;

Raught, B. ;

Stambolic, V. .

SCIENCE, 2013, 341 (6144) :395-399

[9] CTC-derived AR-V7 detection as a prognostic and predictive biomarker in advanced prostate cancer [J].

Bastos, Diogo A. ;

Antonarakis, Emmanuel S. .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2018, 18 (02) :155-163

[10] Risk of Prostate Cancer Associated With Familial and Hereditary Cancer Syndromes [J].

Beebe-Dimmer, Jennifer L. ;

Kapron, Ashley L. ;

Fraser, Alison M. ;

Smith, Ken R. ;

Cooney, Kathleen A. .

JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (16) :1807-+

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