Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis

被引：26
作者：
Wan, D. [1 ]
Gu, W. [2 ]
Xu, G. [3 ]
Shen, C. [2 ]
Ding, D. [2 ]
Shen, S. [1 ]
Wang, S. [1 ]
Gong, X. [1 ]
He, S. [2 ]
Zhi, Q. [2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510006, Guangdong, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Gen Surg, Suzhou 215006, Jiangsu, Peoples R China
[3] Jiangxi Canc Hosp, Dept Diagnose & Treatment Ctr Hepatocellular Carc, Nanchang 330000, Jiangxi, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2014年 / 16卷 / 09期
基金：
美国国家科学基金会;
关键词：
Colorectal cancer; microRNA; Polymorphisms; Meta-analysis; CHINESE POPULATION; HEPATOCELLULAR-CARCINOMA; GENETIC-VARIANTS; MICRORNA; RISK; EPIDEMIOLOGY; ASSOCIATION; PROGRESSION; BIOGENESIS; EXPRESSION;
D O I：
10.1007/s12094-013-1150-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Emerging evidence has shown that single nucleotide polymorphisms occurred in microRNAs may contribute to the development of colorectal cancer (CRC). rs2910164 in miR-146a and rs11614913 in miR-196a2 are suggested to be associated with the susceptibility to CRC, but individually published studies revealed inconclusive results. To systematically summarize the possible correlationship between these polymorphisms and CRC risk, we performed this meta-analysis. We retrieved the relevant articles of the associations between these two microRNA polymorphisms and susceptibility to CRC for the period up to July 1, 2013. A total of seven articles were identified with 2,143 cases and 2,457 controls for miR-146a rs2910164, 1,594 cases and 2,252 controls for miR-196a2 rs11614913. Odds ratio and 95 % confidence interval were calculated to investigate the strength of the association. The pooled analysis showed that miR-146a rs2910164 did not reveal any correlation with CRC susceptibility. However, a decreased risk was observed between miR-196a2 rs11614913 and CRC in all genetic models. Our current meta-analysis demonstrates that miR-196a2 rs11614913 most likely contributes to decreased risk of CRC, whereas miR-146a rs2910164 may not be associated with the susceptibility to CRC.
引用
收藏
页码：792 / 800
页数：9
相关论文
共 36 条
[21]   Association of the miR-146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population [J].
Min, Kyung Tae ;
Kim, Jong Woo ;
Jeon, Young Joo ;
Jang, Moon Ju ;
Chong, So Young ;
Oh, Doyeun ;
Kim, Nam Keun .
MOLECULAR CARCINOGENESIS, 2012, 51 :E65-E73
[22]   Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study [J].
Mitry, Emmanuel ;
Guiu, Boris ;
Cosconea, Simona ;
Jooste, Valerie ;
Faivre, Jean ;
Bouvier, Anne-Marie .
GUT, 2010, 59 (10) :1383-1388
[23]   MicroRNA in TLR signaling and endotoxin tolerance [J].
Nahid, Md A. ;
Satoh, Minoru ;
Chan, Edward K. L. .
CELLULAR & MOLECULAR IMMUNOLOGY, 2011, 8 (05) :388-403
[24]   Commentary: Lifestyle factors and colorectal cancer microsatellite instability-molecular pathological epidemiology science, based on unique tumour principle [J].
Ogino, Shuji ;
Giovannucci, Edward .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2012, 41 (04) :1072-1074
[25]  
Orsós Z, 2013, ANTICANCER RES, V33, P341
[26]  
Pelletier C, 2010, EXPERT REV MOL DIAGN, V10, P817, DOI [10.1586/erm.10.59, 10.1586/ERM.10.59]
[27]   Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk [J].
Srivastava, Kshitij ;
Srivastava, Anvesha .
PLOS ONE, 2012, 7 (11)
[28]   Regulation of microRNA biogenesis and function [J].
Treiber, Thomas ;
Treiber, Nora ;
Meister, Gunter .
THROMBOSIS AND HAEMOSTASIS, 2012, 107 (04) :605-610
[29]   Analysis of microRNA Expression and Function [J].
Van Wynsberghe, Priscilla M. ;
Chan, Shih-Peng ;
Slack, Frank J. ;
Pasquinelli, Amy E. .
CAENORHABDITIS ELEGANS: MOLECULAR GENETICS AND DEVELOPMENT, SECOND EDITION, 2011, 106 :219-252
[30]   Genetic and epigenetic factors in regulation of microRNA in colorectal cancers [J].
Vinci, Serena ;
Gelmini, Stefania ;
Mancini, Irene ;
Malentacchi, Francesca ;
Pazzagli, Mario ;
Beltrami, Cristina ;
Pinzani, Pamela ;
Orlando, Claudio .
METHODS, 2013, 59 (01) :138-146
1234