Model based analysis of hepatitis B vaccination strategies in the Netherlands

被引：26

作者：

Kretzschmar, Mirjam ^{[1
,2
]}

Mangen, Marie-Josee ^{[2
]}

van de Laar, Marita ^{[3
]}

de Wit, Ardine ^{[2
,4
]}

机构：

[1] RIVM, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands

[2] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[3] European Ctr Dis Control, Stockholm, Sweden

[4] RIVM, Dept Prevent & Hlth Serv Res, NL-3720 BA Bilthoven, Netherlands

来源：

VACCINE | 2009年 / 27卷 / 08期

关键词：

Mathematical model; Hepatitis B; Vaccination; VIRUS-INFECTION; MOLECULAR EPIDEMIOLOGY; DRUG-USERS; TRANSMISSION; AMSTERDAM; PROGRAM; ROUTES; IMPACT; MEN; SEX;

D O I：

10.1016/j.vaccine.2008.12.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used a mathematical model for the transmission of hepatitis B infection to compare the effectiveness of different vaccination Strategies in the Netherlands. Vaccination of children of immigrants from high and medium endemic countries is an effective strategy in countries with substantial immigration Of Carriers from high and medium endemic Countries. A targeted vaccination programme for sexually highly active risk groups has a moderate additional effect if continued over a long time period. Universal vaccination has the largest effect on the incidence of new infections at the cost of having to vaccinate many more individuals than in targeted programmes. The impact on the prevalence of chronic hepatitis B infection, however. remains limited. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1254 / 1260

页数：7

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