The MexR repressor of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa:: Characterization of mutations compromising activity

被引：66

作者：

Adewoye, L ^{[1
]}

Sutherland, A ^{[1
]}

Srikumar, R ^{[1
]}

Poole, K ^{[1
]}

机构：

[1] Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 15期

关键词：

D O I：

10.1128/JB.184.15.4308-4312.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutations in mexR yield a multidrug resistance phenotype in nalB mutants of Pseudomonas aeruginosa as a result of derepression of the mex4B-oprM multidrug efflux operon. MexR produced by several nalB strains carried single amino acid changes that compromised MexR stability or its ability to dimerize. Changes at residues L95 and R21, however, produced a stable MexR protein capable of dimerization and, thus, likely compromised DNA binding.

引用

页码：4308 / 4312

页数：5

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