Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action

被引：22

作者：

Jezkova, Lucie ^{[1
,2
,3
]}

Falk, Martin ^{[1
]}

Falkova, Iva ^{[1
,4
]}

Davidkova, Marie ^{[5
]}

Bacikova, Alena ^{[1
]}

Stefancikova, Lenka ^{[1
]}

Vachelova, Jana ^{[5
]}

Michaelidesova, Anna ^{[5
]}

Lukasova, Emilie ^{[1
]}

Boreyko, Alla ^{[2
]}

Krasavin, Evgeny ^{[2
]}

Kozubek, Stanislav ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Biophys, CS-61265 Brno, Czech Republic

[2] Joint Inst Nucl Res, Dubna, Moscow Region, Russia

[3] Prague Inst Chem Technol, CR-16628 Prague, Czech Republic

[4] Fac Hosp Brno, Clin Internal Med Hematol & Oncol, Brno, Czech Republic

[5] Acad Sci Czech Republic, Inst Nucl Phys, CZ-25068 Rez, Czech Republic

来源：

APPLIED RADIATION AND ISOTOPES | 2014年 / 83卷

关键词：

DNA double-strand breaks (DSBs); Higher-order chromatin structure and DSB repair; Formation of chromosomal translocations; Gamma rays and proton beams; gamma H2AX foci; DOUBLE-STRAND BREAKS; HISTONE H2AX PHOSPHORYLATION; HUMAN TRANSCRIPTOME MAP; CHROMOSOME TERRITORIES; EXPRESSED GENES; HUMAN-CELLS; DSB REPAIR; RADIATION; DOMAINS; HETEROCHROMATIN;

D O I：

10.1016/j.apradiso.2013.01.022

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：128 / 136

页数：9

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