TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses

被引：159

作者：

Xu, Yan-Ran ^{[1
]}

Lei, Cao-Qi ^{[1
]}

机构：

[1] Wuhan Univ, Coll Life Sci, Frontier Sci Ctr Immunol & Metab, State Key Lab Virol,Hubei Key Lab Cell Homeostasi, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

TAK1; TABs; post-translational modifications; NF-kappa B; inflammation; NF-KAPPA-B; NONHISTONE PROTEIN METHYLATION; UBIQUITIN-DEPENDENT KINASE; TOLL-LIKE RECEPTORS; MEDIATED ACTIVATION; SIGNALING PATHWAY; TAK1; ACTIVATION; O-GLCNACYLATION; TARGETING TAK1; IKK ACTIVATION;

D O I：

10.3389/fimmu.2020.608976

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding proteins (TAB1, TAB2, and TAB3) and can be activated by a variety of stimuli such as tumor necrosis factor alpha (TNF alpha), interleukin-1 beta (IL-1 beta), and toll-like receptor ligands, and they play essential roles in the activation of NF-kappa B and MAPKs. Numerous studies have demonstrated that post-translational modifications play important roles in properly controlling the activity, stability, and assembly of TAK1-TABs complex according to the indicated cellular environment. This review focuses on the recent advances in TAK1-TABs-mediated signaling and the regulations of TAK1-TABs complex by post-translational modifications.

引用

页数：12

共 136 条

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