Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort

被引：18

作者：

Giannella, Maddalena ^{[1
,2
]}

Righi, Elda ^{[3
]}

Pascale, Renato ^{[1
,2
]}

Rinaldi, Matteo ^{[1
,2
]}

Caroccia, Natascia ^{[1
,2
]}

Gamberini, Chiara ^{[4
]}

Palacios-Baena, Zaira R. ^{[5
,6
,7
]}

Caponcello, Giulia ^{[5
,6
,7
]}

Morelli, Maria Cristina ^{[8
]}

Tame, Mariarosa ^{[9
]}

Busutti, Marco ^{[10
]}

Comai, Giorgia ^{[10
]}

Potena, Luciano ^{[11
]}

Salvaterra, Elena ^{[12
]}

Feltrin, Giuseppe ^{[13
]}

Cillo, Umberto ^{[14
]}

Gerosa, Gino ^{[15
]}

Cananzi, Mara ^{[16
]}

Piano, Salvatore ^{[17
]}

Benetti, Elisa ^{[18
]}

Burra, Patrizia ^{[19
]}

Loy, Monica ^{[20
]}

Furian, Lucrezia ^{[21
]}

Zaza, Gianluigi ^{[22
]}

Onorati, Francesco ^{[23
]}

Carraro, Amedeo ^{[24
]}

Gastaldon, Fiorella ^{[25
]}

Nordio, Maurizio ^{[26
]}

Kumar-Singh, Samir ^{[27
]}

Abedini, Mahsa ^{[2
]}

Boffetta, Paolo ^{[2
,28
]}

Rodriguez-Bano, Jesus ^{[5
,6
,7
]}

Lazzarotto, Tiziana ^{[4
]}

Viale, Pierluigi ^{[1
,2
]}

Tacconelli, Evelina ^{[3
]}

机构：

[1] IRCCS Azienda Osped Univ Bologna, Dept Integrated Management Infect Risk, Infect Dis Unit, I-40138 Bologna, Italy

[2] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy

[3] Univ Verona, Dept Diagnost & Publ Hlth, Div Infect Dis, I-37134 Verona, Italy

[4] Univ Bologna, Microbiol Unit, IRCCS Policlin St Orsola, I-40138 Bologna, Italy

[5] Univ Seville, Biomed Inst Sevilla, CSIC, Infect Dis & Microbiol Unit,Hosp Univ Virgen Maca, Seville 41009, Spain

[6] Univ Seville, Biomed Inst Sevilla, CSIC, Dept Med, Seville 41009, Spain

[7] Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain

[8] IRCCS Azienda Osped Univ Bologna, Internal Med Unit Treatment Severe Organ Failure, I-40138 Bologna, Italy

[9] IRCCS Azienda Osped Univ Bologna, Dept Digest Hepat & Endocrine Metab Dis, Gastroenterol Unit, I-40138 Bologna, Italy

[10] IRCCS Azienda Osped Univ Bologna, Dept Expt Diagnost & Specialty Med, Nephrol Dialysis & Transplantat Unit, I-40138 Bologna, Italy

[11] IRCCS Azienda Osped Univ Bologna, Heart Failure & Transplant Unit, I-40138 Bologna, Italy

[12] IRCCS Azienda Osped Univ Bologna, Div Intervent Pulmonol Unit, I-40138 Bologna, Italy

[13] Reg Ctr Transplant Coordinat, I-35128 Padua, Italy

[14] Padua Univ Hosp, Dept Surg Oncol & Gastroenterol, Hepatobiliary Surg & Liver Transplantat Unit, I-35128 Padua, Italy

[15] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Cardiac Surg Unit, I-35128 Padua, Italy

[16] Univ Hosp Padua, Dept Womens & Childrens Hlth, Unit Pediat Gastroenterol Digest Endoscopy Hepato, I-35128 Padua, Italy

[17] Univ Padua, Dept Med DIMED, Unit Internal Med & Hepatol UIMH, I-35128 Padua, Italy

[18] Padua Univ Hosp, Dept Womens & Childrens Hlth, Pediat Nephrol Dialysis & Transplant Unit, I-35128 Padua, Italy

[19] Univ Hosp Padua, Dept Surg Oncol & Gastroenterol, Unit Gastroenterol & Multivisceral Transplant, I-35128 Padua, Italy

[20] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Thorac Surg Unit, I-35128 Padua, Italy

[21] Univ Padua, Dept Surg Oncol & Gastroenterol Sci, Kidney & Pancreas Transplantat Unit, I-35128 Padua, Italy

[22] Univ Hosp Verona, Dept Med, Renal Unit, I-37134 Verona, Italy

[23] Univ Verona, Div Cardiac Surg, I-37134 Verona, Italy

[24] Univ & Hosp Trust Verona, Dept Surg & Dent, Liver Transplant Unit, I-37134 Verona, Italy

[25] San Bortolo Hosp, Dept Nephrol Dialysis & Transplantat, I-36100 Vicenza, Italy

[26] Treviso Hosp, Nephrol Dialysis & Transplantat Unit, I-35121 Treviso, Italy

[27] Univ Antwerp, Fac Med, Mol Pathol Grp, Lab Cell Biol & Histol, B-2610 Antwerp, Belgium

[28] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA

来源：

MICROORGANISMS | 2022年 / 10卷 / 05期

关键词：

COVID-19; mRNA vaccines; serology; antibody response; solid organ transplantation;

D O I：

10.3390/microorganisms10051021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering the analysis of AbR kinetics. We present the ORCHESTRA SOT recipients cohort assessed for AbR at first dose (t0), second dose (t1), and within 3 +/- 1 month (t2) after the first dose. We analyzed 1062 SOT patients (kidney, 63.7%; liver, 17.4%; heart, 16.7%; and lung, 2.5%) and 5045 health care workers (HCWs). The AbR rates in the SOTs and HCWs were 52.3% and 99.4%. The antibody levels were significantly higher in the HCWs than in the SOTs (p < 0.001). The kinetics showed an increase (p < 0.001) in antibody levels up to 76 days and a non-significant decrease after 118 days in the SOT recipients versus a decrease up to 76 days (p = 0.02) and a less pronounced decrease between 76 and 118 days (p = 0.04) in the HCWs. Upon multivariable analysis, liver transplant, >= 3 years from SOT, mRNA-1273, azathioprine, and longer time from t0 were associated with a positive AbR at t2. Older age, other comorbidities, mycophenolate, steroids, and impaired graft function were associated with lower AbR probability. Our results may be useful to optimize strategies of immune monitoring after COVID-19 vaccination and indications regarding timing for booster dosages calibrated on SOT patients' characteristics.

引用

页数：13

共 36 条

[1]

Achard J.M., 2021, J AM SOC NEPHROL, V32, P2153, DOI DOI 10.1681/ASN.2021040490

[2] Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine [J].

Benotmane, Ilies ;

Gautier-Vargas, Gabriela ;

Cognard, Noelle ;

Olagne, Jerome ;

Heibel, FrancOise ;

Braun-Parvez, Laura ;

Martzloff, Jonas ;

Perrin, Peggy ;

Moulin, Bruno ;

Fafi-Kremer, Samira ;

Caillard, Sophie .

KIDNEY INTERNATIONAL, 2021, 99 (06) :1498-1500

[3] Antibody Kinetics and Durability in SARS-CoV-2 mRNA Vaccinated Solid Organ Transplant Recipients [J].

Boyarsky, Brian J. ;

Chiang, Teresa P. -Y. ;

Teles, Aura T. ;

Greenberg, Ross S. ;

Krach, Michelle R. ;

Ou, Michael T. ;

Massie, Allan B. ;

Tobian, Aaron A. R. ;

Garonzik-Wang, Jacqueline M. ;

Segev, Dorry L. ;

Werbel, William A. .

TRANSPLANTATION, 2021, 105 (10) :E137-E138

[4] Antibody Response to the Janssen COVID-19 Vaccine in Solid Organ Transplant Recipients [J].

Boyarsky, Brian J. ;

Chiang, Teresa P. -Y. ;

Ou, Michael T. ;

Werbel, William A. ;

Massie, Allan B. ;

Segev, Dorry L. ;

Garonzik-Wang, Jacqueline M. .

TRANSPLANTATION, 2021, 105 (08) :E82-E83

[5] Poor Anti-SARS-CoV-2 Humoral and T-cell Responses After 2 Injections of mRNA Vaccine in Kidney Transplant Recipients Treated With Belatacept [J].

Chavarot, Nathalie ;

Ouedrani, Amani ;

Marion, Olivier ;

Leruez-Ville, Marianne ;

Vilain, Estelle ;

Baaziz, Maroua ;

Del Bello, Arnaud ;

Burger, Carole ;

Sberro-Soussan, Rebecca ;

Martinez, Frank ;

Chatenoud, Lucienne ;

Abravanel, Florence ;

Anglicheau, Dany ;

Izopet, Jacques ;

Couat, Chloe ;

Zuber, Julien ;

Legendre, Christophe ;

Lanternier, Fanny ;

Kamar, Nassim ;

Scemla, Anne .

TRANSPLANTATION, 2021, 105 (09) :E94-E95

[6] Clinical Factors Associated With Lack of Serological Response to SARS-CoV-2 Messenger RNA Vaccine in Liver Transplantation Recipients [J].

Cholankeril, George ;

Al-Hillan, Alsadiq ;

Tarlow, Brandon ;

Abrams, Daniela ;

Jacobs, Jake S. ;

Flores, Norma P. ;

Rana, Abbas ;

Kanwal, Fasiha ;

Goss, John A. .

LIVER TRANSPLANTATION, 2022, 28 (01) :123-126

[7] Cellular and humoral response after MRNA-1273 SARS-CoV-2 vaccine in kidney transplant recipients [J].

Cucchiari, David ;

Egri, Natalia ;

Bodro, Marta ;

Herrera, Sabina ;

Del Risco-Zevallos, Jimena ;

Casals-Urquiza, Joaquim ;

Cofan, Frederic ;

Moreno, Asuncion ;

Rovira, Jordi ;

Banon-Maneus, Elisenda ;

Ramirez-Bajo, Maria J. ;

Ventura-Aguiar, Pedro ;

Perez-Olmos, Anna ;

Garcia-Pascual, Marta ;

Pascal, Mariona ;

Vilella, Anna ;

Trilla, Antoni ;

Rios, Jose ;

Palou, Eduard ;

Juan, Manel ;

Bayes, Beatriu ;

Diekmann, Fritz .

AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 (08) :2727-2739

[8] Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study-The COViNEPH Project [J].

Debska-Slizien, Alicja ;

Slizien, Zuzanna ;

Muchlado, Marta ;

Kubanek, Alicja ;

Piotrowska, Magdalena ;

Dabrowska, Malgorzata ;

Tarasewicz, Agnieszka ;

Chamienia, Andrzej ;

Biedunkiewicz, Bogdan ;

Renke, Marcin ;

Tylicki, Leszek .

VACCINES, 2021, 9 (10)

[9] Winter of Omicron-The Evolving COVID-19 Pandemic [J].

del Rio, Carlos ;

Omer, Saad B. ;

Malani, Preeti N. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (04) :319-320

[10] COVID-19 in Immunocompromised Hosts: What We Know So Far [J].

Fung, Monica ;

Babik, Jennifer M. .

CLINICAL INFECTIOUS DISEASES, 2021, 72 (02) :340-350

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