Phospholipase A2 enzymes:: structural diversity in lipid messenger metabolism

被引:26
作者
Dessen, A [1 ]
机构
[1] European Mol Biol Lab, F-38000 Grenoble, France
来源
STRUCTURE WITH FOLDING & DESIGN | 2000年 / 8卷 / 02期
关键词
D O I
10.1016/S0969-2126(00)00097-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The:phospholipases A(2) (PLA(2)s) are a large family of enzymes: with varied lipidic products which are involved in numerous signal transduction pathways, The structural and:functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.
引用
收藏
页码:R15 / R22
页数:8
相关论文
共 65 条
[1]   INHIBITION OF MACROPHAGE CA2+-INDEPENDENT PHOSPHOLIPASE A(2) BY BROMOENOL LACTONE AND TRIFLUOROMETHYL KETONES [J].
ACKERMANN, EJ ;
CONDEFRIEBOES, K ;
DENNIS, EA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) :445-450
[2]  
BALBOA MA, 1997, J CELL BIOL, V272, P8676
[3]   Regulation and inhibition of phospholipase A2 [J].
Balsinde, J ;
Balboa, MA ;
Insel, PA ;
Dennis, EA .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 :175-189
[4]   Function and inhibition of intracellular calcium-independent phospholipase A(2) [J].
Balsinde, J ;
Dennis, EA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) :16069-16072
[5]   Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A(2) [J].
Bonventre, JV ;
Huang, ZH ;
Taheri, MR ;
OLeary, E ;
Li, E ;
Moskowitz, MA ;
Sapirstein, A .
NATURE, 1997, 390 (6660) :622-625
[6]   A NOVEL ARACHIDONIC ACID-SELECTIVE CYTOSOLIC PLA2 CONTAINS A CA2+-DEPENDENT TRANSLOCATION DOMAIN WITH HOMOLOGY TO PKC AND GAP [J].
CLARK, JD ;
LIN, LL ;
KRIZ, RW ;
RAMESHA, CS ;
SULTZMAN, LA ;
LIN, AY ;
MILONA, N ;
KNOPF, JL .
CELL, 1991, 65 (06) :1043-1051
[7]  
DENNIS EA, 1994, J BIOL CHEM, V269, P13057
[8]   The growing phospholipase A(2) superfamily of signal transduction enzymes [J].
Dennis, EA .
TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) :1-2
[9]   A TWIST IN THE TALE OF LIPOLYTIC ENZYMES [J].
DEREWENDA, ZS .
NATURE STRUCTURAL BIOLOGY, 1995, 2 (05) :347-349
[10]   Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism [J].
Dessen, A ;
Tang, J ;
Schmidt, H ;
Stahl, M ;
Clark, JD ;
Seehra, J ;
Somers, WS .
CELL, 1999, 97 (03) :349-360