Intracranial Atypical Teratoid/Rhabdoid Tumor Presenting as an Axillary Mass: A Case Report and Review of Literature

被引：2

作者：

Bush, Jonathan W. ^{[1
]}

Hancock, B. J. ^{[2
,3
]}

Israels, Sara J. ^{[3
,4
]}

Ellison, David W. ^{[5
]}

Stefanovici, Camelia ^{[1
]}

Krawitz, Sherry ^{[1
]}

机构：

[1] Univ Manitoba, Dept Pathol, Winnipeg, MB R3T 2N2, Canada

[2] Univ Manitoba, Dept Surg, Winnipeg, MB R3T 2N2, Canada

[3] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada

[4] CancerCare Manitoba, Winnipeg, MB, Canada

[5] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2014年 / 17卷 / 02期

关键词：

atypical teratoid rhabdoid tumor; metastasis; CENTRAL-NERVOUS-SYSTEM; TERATOID RHABDOID TUMOR; EXTRANEURAL METASTASIS; CHILDHOOD; MUTATIONS; EXPERIENCE; HSNF5/INI1; INFANCY; KIDNEY; BRAIN;

D O I：

10.2350/14-01-1427-CR.1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon, high-grade pediatric malignancy of the central nervous system (CNS) that rarely metastasizes outside the CNS (Chang stage M4). We describe a child with the sole metastasis of an AT/RT to an axillary lymph node and no other site of extra-CNS disease at presentation. The tumor included areas of rhabdoid cells and failed to express the SMARCB1 gene product (INI1). The metastatic site in this patient is unusual for 3 reasons: (1) it is anatomically unexpected for a CNS tumor, (2) no other extra-CNS metastasis or primary tumor outside the CNS was found, and (3) no cardiac septal defect or vascular anomaly was identified. This site as the presenting lesion and sole metastasis of an intracranial AT/RT has not been previously reported. We attempt to explain this phenomenon.

引用

页码：122 / 125

页数：4

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