An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones

被引：8
作者：
Ghosh, Arun K. [1 ]
Chen, Zhi-Hua
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 22期
基金：
美国国家卫生研究院;
关键词：
ALKALOIDS; FUNCTIONALIZATION; INHIBITORS;
D O I：
10.1039/c4ob00511b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient intramolecular N/O-nucleophilic cyclization of 2-aryl indoles has been developed to afford the corresponding 2-aza-3-oxaindolines and 3-indolinones in 80-95% yield. The methods provided convenient access to fused imidazo[1,2-c]oxazolidinone, oxazolidine, or tetrahydro-1,3-oxazine cores under mild conditions.
引用
收藏
页码：3567 / 3571
页数：5
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