Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

被引：137
作者：
Hou, Guo-Hua
Xie, Jian-Hua
Yan, Pu-Cha
Zhou, Qi-Lin [1 ]
机构：
[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 04期
基金：
中国国家自然科学基金;
关键词：
AMINO-ACID-DERIVATIVES; ENANTIOSELECTIVE HYDROGENATION; ALLYLIC AMINATION; LIGANDS; PHOSPHORAMIDITE; ETHERIFICATION; COMPLEXES; ALKALOIDS; ARYL;
D O I：
10.1021/ja808358r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first highly enantioselective iridium-catatyzed hydrogenation of cyclic enamines has been developed. This new reaction provided an efficient method for the synthesis of optically active cyclic tertiary amines including natural product crispine A.
引用
收藏
页码：1366 / +
页数：3
相关论文
共 50 条
  • [21] Iridium-Catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated γ-Lactams: Scope and Mechanistic Studies
    Yuan, Qianjia
    Liu, Delong
    Zhang, Wanbin
    ORGANIC LETTERS, 2017, 19 (05) : 1144 - 1147
  • [22] Synthesis of Chiral Hydantoins and Thiazolidinediones via Iridium-Catalyzed Asymmetric Hydrogenation
    Nie, Yu
    Li, Jing
    Yuan, Qianjia
    Zhang, Wanbin
    CHINESE JOURNAL OF CHEMISTRY, 2022, 40 (07) : 819 - 824
  • [23] Iridium-catalyzed asymmetric hydrogenation of dibenzo[b,f][1,4]thiazepines
    Guo, Ran-Ning
    Gao, Kai
    Ye, Zhi-Shi
    Shi, Lei
    Li, Yanqin
    Zhou, Yong-Gui
    PURE AND APPLIED CHEMISTRY, 2013, 85 (04) : 843 - 849
  • [24] Iridium-Catalyzed Asymmetric Hydrogenation of N-Protected Indoles
    Baeza, Alejandro
    Pfaltz, Andreas
    CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (07) : 2036 - 2039
  • [25] Iridium-Catalyzed Asymmetric Hydrogenation of γ- and δ-Ketoacids for Enantioselective Synthesis of γ- and δ-Lactones
    Hua, Yun-Yu
    Bin, Huai-Yu
    Wei, Tao
    Cheng, Hou-An
    Lin, Zu-Peng
    Fu, Xing-Feng
    Li, Yuan-Qiang
    Xie, Jian-Hua
    Yan, Pu-Cha
    Zhou, Qi-Lin
    ORGANIC LETTERS, 2020, 22 (03) : 818 - 822
  • [26] Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of β-Keto Ester
    Xu, Qian
    Gou, Wenchang
    Dai, Pinli
    Zhou, Xuan
    Tian, Jie
    Meng, Xin
    Tian, Yu
    Zhang, Lin
    Li, Chun
    JOURNAL OF ORGANIC CHEMISTRY, 2024, 89 (03) : 1446 - 1457
  • [27] Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins
    Yin, Congcong
    Wu, Weilong
    Hu, Yang
    Tan, Xuefeng
    You, Cai
    Liu, Yuanhua
    Chen, Ziyi
    Dong, Xiu-Qin
    Zhang, Xumu
    ADVANCED SYNTHESIS & CATALYSIS, 2018, 360 (11) : 2119 - 2124
  • [28] Highly Efficient Iridium-Catalyzed Asymmetric Hydrogenation of Unprotected β-Enamine Esters
    Hou, Guohua
    Li, Wei
    Ma, Miaofeng
    Zhang, Xiaowei
    Zhang, Xumu
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (37) : 12844 - 12846
  • [29] Iridium-catalyzed asymmetric hydrogenation of racemic α-substituted lactones to chiral diols
    Yang, Xiao-Hui
    Yue, Hai-Tao
    Yu, Na
    Li, Yi-Pan
    Xie, Jian-Hua
    Zhou, Qi-Lin
    CHEMICAL SCIENCE, 2017, 8 (03) : 1811 - 1814
  • [30] Iridium-catalyzed asymmetric hydrogenation of olefins using TIQ phosphine-oxazoline ligands
    Chakka, Sai Kumar
    Peters, Byron K.
    Andersson, Pher G.
    Maguire, Glenn E. M.
    Kruger, Hendrik G.
    Govender, Thavendran
    TETRAHEDRON-ASYMMETRY, 2010, 21 (18) : 2295 - 2301
12345