What's new in ion transports in the cochlea?

被引：24

作者：

Couloigner, Vincent

Sterkers, Olivier

Ferrary, Evelyne

机构：

[1] Fac Xavier Bichat, INSERM, EMI, U0112, F-75018 Paris, France

[2] Hop Necker Enfants Malad, APHP, Pediat ENT Dept, Paris, France

[3] Hop Beaujon, APHP, ENT Dept, Paris, France

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2006年 / 453卷 / 01期

关键词：

inner ear fluids; potassium; sodium; acid-base; endolymph; connexin; hearing; deafness;

D O I：

10.1007/s00424-006-0103-4

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K+ through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K+ by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K+ recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.

引用

页码：11 / 22

页数：12

共 67 条

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