Effect of type 2 diabetes mellitus on flavonoid pharmacokinetics and tissue distribution after oral administration of Radix Scutellaria extract in rats

被引：0

作者：

Zhang Xue-Ju ^{[1
,2
]}

Liu Shu ^{[1
]}

Xing Jun-Peng ^{[1
]}

Liu Zhi-Qiang ^{[1
]}

Song Feng-Rui ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Jilin Prov Key Lab Chinese Med Chem & Mass Spectr, Natl Ctr Mass Spectrometry Changchun, Changchun 130022, Jilin, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2018年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Radix Scutellaria; Diabetes mellitus; Flavonoid; Pharmacokinetics; Tissue distribution; TRADITIONAL CHINESE MEDICINE; MASS-SPECTROMETRY; OROXYLIN; BAICALIN; EXPRESSION; WOGONOSIDE; COMPLICATIONS; INHIBITORS; WOGONIN; PLASMA;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Radix Scutellaria is widely applied to the treatment of diabetes mellitus in China. Its main bioactive constituents contain baicalin, wogonoside, oroxyloside, and their aglycones. To investigate the effect of type 2 diabetes mellitus on both pharmacokinetics and tissue distribution of these flavonoid compounds, the six flavonoids in plasma and tissues from the normal and type 2 diabetic rats after oral administration of Radix Scutellaria extract were simultaneously measured by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. The results showed that baicalin, wogonoside, and oroxyloside had higher C(max)and AUC values (P < 0.05) in type 2 diabetic rats than that in normal rats and the tissue-distribution behaviors of the six flavonoid compounds in hearts, livers, spleens, lungs, kidneys, brains, pancreas, fat and muscle of the type 2 diabetic rats showed obviously differences from the normal rats (P < 0.05). In conclusion, the differences in the pharmacokinetics of oroxyloside and tissue distribution of the six flavanoids in Radix Scutellaria extract between diabetic and normal rats were found for the first time. The results from the present study provided a crucial basis for a better understanding of in vivo anti-diabetic mechanism of action of the six flavonoids from Radix Scutellaria.

引用

页码：418 / 427

页数：10

共 34 条

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[2]

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