Pathogenesis of muscle weakness in inflammatory myositis

被引：3

作者：

Dunga, Sai Kumar ^{[1
]}

Sundaram, T. G. ^{[2
]}

Kavadichanda, Chengappa G. ^{[1
]}

机构：

[1] Jawaharlal Inst Postgrad Med Educ & Res, Dept Clin Immunol, Pondicherry, India

[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Clin Immunol & Rheumatol, Lucknow, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF RHEUMATOLOGY | 2020年 / 15卷 / 06期

关键词：

Dermatomyositis; etiology; inflammatory myositis; muscle weakness; pathogenesis; polymyositis; ENDOPLASMIC-RETICULUM STRESS; INCLUSION-BODY MYOSITIS; FOLLISTATIN GENE-THERAPY; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTOR-3; SKELETAL-MUSCLE; T-CELLS; KAPPA-B; CLASS-I; AUTOIMMUNE MYOSITIS;

D O I：

10.4103/injr.injr_120_20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Idiopathic inflammatory myositis (IIM) is a heterogeneous group of autoimmune diseases. These are characterized by muscle weakness and fatigue along with other systemic manifestations, ranging from pulmonary alveolitis to vasculopathic ulcers. Muscle weakness is encountered in a majority of individuals with IIM. Several hypotheses for muscle weakness have been proposed, but none have been convincingly proven. Understanding of the pathophysiology of muscle weakness is necessary to better delineate therapeutic options and tailor exercise regimens in patients with IIM. In this review, we have attempted to delineate the immune and nonimmune pathways implicated in muscle weakness and integrated them with the clinical, histopathological, and imaging findings in IIM.

引用

页码：99 / 111

页数：13

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