Myopathy in thiamine deficiency: Analysis of a case

被引：19

作者：

Koike, Haruki ^{[1
]}

Watanabe, Hirohisa ^{[1
]}

Inukai, Akira ^{[1
]}

Iijima, Masahiro ^{[1
]}

Mori, Keiko ^{[1
]}

Hattori, Naoki ^{[1
]}

Sobue, Gen ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Neurol, Nagoya, Aichi 4668550, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2006年 / 249卷 / 02期

关键词：

thiamine deficiency; beriberi; neuropathy; myopathy; muscle biopsy;

D O I：

10.1016/j.jns.2006.06.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Tenderness in the limb muscles has been reported anecdotally in patients with beriberi neuropathy, but clinical effects of thiamine deficiency on skeletal muscle have received little attention. Objective: To describe a patient with thiamine deficiency who manifested myopathic symptoms and responded well to thiamine supplementation. Patient: A 26-year-old woman with neuropathy and heart failure associated with thiamine deficiency also complained of myalgia and weakness, most troublesome in the proximal portions of the limbs. Results: Serum creatine kinase, myoglobin, and aldolase concentrations were abnormally elevated. Magnetic resonance imaging of lower limb muscles demonstrated areas of high signal intensity in T2-weighted images and showed Gd-DTPA enhancement. A biopsy specimen from the quadriceps muscle showed myopathic changes without neurogenic changes. Abnormalities improved well with thiamine administration. Conclusion: Myopathy may occur in patients with thiamine deficiency. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：175 / 179

页数：5

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