Tetrabutylammonium bromide:: an efficient media for dimethoxytritylation of the 5′-hydroxyl function of nucleosides

被引：34

作者：

Khalafi-Nezhad, A ^{[1
]}

Mokhtari, B ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 36期

关键词：

protection; nucleosides; dimethoxytritylation; ionic liquids; molten salts;

D O I：

10.1016/j.tetlet.2004.07.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure for selective dimethoxytritylation of the 5'-hydroxyl function of nucleosides in the presence of DABCO in molten tetrabutylammonium bromide is described. The methodology is very practical, environmentally benign and produced the desired product in less than 5 min by grinding in a hot mortar. In addition, the effects of the room temperature ionic liquid (1-butyl-3-methylimidazolium chloride) and microwave irradiation on this system were also studied and the results showed that depurination of the nucleosides occurred under microwave irradiation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6737 / 6739

页数：3

共 24 条

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