共 50 条
What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review
被引:10
|作者:
Malandrini, Sabrina
[1
]
Trimboli, Pierpaolo
[2
,3
]
Guzzaloni, Gabriele
[2
]
Virili, Camilla
[4
]
Lucchini, Barbara
[2
,3
]
机构:
[1] Reg Hosp Locarno, Dept Internal Med, CH-6600 Locarno, Switzerland
[2] Ente Osped Cantonale EOC, Clin Endocrinol, CH-6500 Bellinzona, Switzerland
[3] Univ Svizzera Italiana USI, Fac Biomed Sci, CH-6900 Lugano, Switzerland
[4] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy
来源:
关键词:
thyroid hormones;
thyroid antibodies;
celiac disease;
gluten-free diet;
systematic review;
PREVALENCE;
D O I:
10.3390/nu14081681
中图分类号:
R15 [营养卫生、食品卫生];
TS201 [基础科学];
学科分类号:
100403 ;
摘要:
The prevalence of celiac disease (CD) in patients with chronic autoimmune thyroiditis (CAIT) is estimated to be between 2 and 7.8%. A gluten-free diet (GFD) in patients with CD is suggested to have a beneficial effect on CAIT. Thus, the present systematic review was undertaken to achieve more robust evidence about the change in thyroid stimulating hormone (TSH) and thyroid-specific antibodies (T-Ab) levels obtained in CD patients following a GFD. A specific search strategy was planned. The last search was performed on March 2022. The following data were mainly searched for in order to be extracted: sample size, mean and/or median with standard deviation (SD), and error (SE), individually, of thyroid hormones and T-Ab at baseline and after GFD, and the duration of the study. The initial search retrieved 297 records and 6 articles met the inclusion criteria. In total, 50 patients with both CD and CAIT and 45 controls were reported. The effects of a GFD on the thyroid hormonal and immunological profile could be extracted only in a part of the studies. Two studies were case reports. A low risk of bias was observed. These findings advise further studies, ideally randomized, in order to better investigate the potential relationship between GFD and thyroid homeostasis. The level of evidence is not still sufficient to recommend GFD to patients with CAIT.
引用
收藏
页数:8
相关论文