Synthesis and antimicrobial activity of new urea and thiourea derivatives of (2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine

被引：20

作者：

Vedavathi, Pandreti ^{[1
]}

Sudhamani, Hasti ^{[1
]}

Raju, Chamarthi Naga ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 05期

关键词：

Isocyanates; Isothiocyanates; (2 '-(1H-Tetrazol-5-yl)biphenyl-4-yl)methanamine; Antibacterial activity; Antifungal activity; II RECEPTOR ANTAGONISTS; BIOLOGICAL-ACTIVITY; NITRILE IMINES; GENERATION; DISCOVERY; POTENT;

D O I：

10.1007/s11164-016-2823-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of a series of novel urea and thiourea derivatives of (2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine (valsartan intermediate) (1) was accomplished by reaction of 1 with various substituted aryl isocyanates and aryl isothiocyanates in presence of N,N-dimethylpiperazine (DMP). All synthesized compounds were evaluated for their antibacterial and antifungal activities and their minimum inhibitory concentration (MIC) values determined. A few of the title compounds showed good in vitro antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The title compounds also exhibited high antifungal activity. The title compounds were characterized by infrared (IR), H-1 and C-13 nuclear magnetic resonance (NMR), and mass spectral data.

引用

页码：3251 / 3263

页数：13

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