External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study

被引：22

作者：

Foschi, Francesco Giuseppe ^{[1
]}

Conti, Fabio ^{[1
]}

Domenicali, Marco ^{[2
]}

Giacomoni, Pierluigi ^{[1
]}

Borghi, Alberto ^{[2
]}

Bevilacqua, Vittoria ^{[1
]}

Napoli, Lucia ^{[1
]}

Berardinelli, Dante ^{[1
]}

Altini, Mattia ^{[1
]}

Cucchetti, Alessandro ^{[2
]}

Ercolani, Giorgio ^{[2
]}

Casadei-Gardini, Andrea ^{[3
]}

Bellentani, Stefano ^{[4
]}

Gastaldelli, Amalia ^{[5
]}

Tiribelli, Claudio ^{[4
]}

Bedogni, Giorgio ^{[4
]}

机构：

[1] Osped Infermi, Azienda Unita Sanit Romagna, I-48018 Faenza, Italy

[2] Univ Bologna, Fac Med & Surg, I-40138 Bologna, Italy

[3] Univ Modena & Reggio Emilia, Fac Med & Surg, I-41121 Modena, Italy

[4] Italian Liver Fdn, I-34012 Basovizza, Italy

[5] Italian Natl Res Council, I-56124 Pisa, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 03期

关键词：

cross-sectional study; diagnostic techniques and procedures; validation study; fatty liver; non-alcoholic fatty liver disease; DISEASE; PREDICTION; MODEL; ULTRASONOGRAPHY; BIOMARKERS; DIAGNOSIS; NAFLD;

D O I：

10.3390/jcm10030520

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned.

引用

页码：1 / 14

页数：13

共 31 条

[1] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].

Alberti, K. G. M. M. ;

Eckel, Robert H. ;

Grundy, Scott M. ;

Zimmet, Paul Z. ;

Cleeman, James I. ;

Donato, Karen A. ;

Fruchart, Jean-Charles ;

James, W. Philip T. ;

Loria, Catherine M. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2009, 120 (16) :1640-1645

[2]

[Anonymous], 1991, ANTHROPOMETRIC STAND

[3]

[Anonymous], 2016, Diabetologia, V64, P1388, DOI DOI 10.1016/J.JHEP.2015.11.004

[4] Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos Nutrition and Liver Study [J].

Bedogni, G ;

Miglioli, L ;

Masutti, F ;

Tiribelli, C ;

Marchesini, G ;

Bellentani, S .

HEPATOLOGY, 2005, 42 (01) :44-52

[5] The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population [J].

Bedogni, Giorgio ;

Bellentani, Stefano ;

Miglioli, Lucia ;

Masutti, Flora ;

Passalacqua, Marilena ;

Castiglione, Anna ;

Tiribelli, Claudio .

BMC GASTROENTEROLOGY, 2006, 6 (1)

[6] A simple index of lipid overaccumulation is a good marker of liver steatosis [J].

Bedogni, Giorgio ;

Kahn, Henry S. ;

Bellentani, Stefano ;

Tiribelli, Claudio .

BMC GASTROENTEROLOGY, 2010, 10

[7]

Collins GS, 2015, ANN INTERN MED, V162, P55, DOI [10.1038/bjc.2014.639, 10.7326/M14-0697, 10.1002/bjs.9736, 10.1016/j.jclinepi.2014.11.010, 10.1186/s12916-014-0241-z, 10.1111/eci.12376, 10.1136/bmj.g7594, 10.7326/M14-0698, 10.1016/j.eururo.2014.11.025]

[8]

Ensor J, 2018, STAT SOFTWARE COMPON

[9] A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement [J].

Eslam, Mohammed ;

Newsome, Philip N. ;

Sarin, Shiv K. ;

Anstee, Quentin M. ;

Targher, Giovanni ;

Romero-Gomez, Manuel ;

Zelber-Sagi, Shira ;

Wong, Vincent Wai-Sun ;

Dufour, Jean-Francois ;

Schattenberg, Joern M. ;

Kawaguchi, Takumi ;

Arrese, Marco ;

Valenti, Luca ;

Shiha, Gamal ;

Tiribelli, Claudio ;

Yki-Jarvinen, Hannele ;

Fan, Jian-Gao ;

Gronbaek, Henning ;

Yilmaz, Yusuf ;

Cortez-Pinto, Helena ;

Oliveira, Claudia P. ;

Bedossa, Pierre ;

Adams, Leon A. ;

Zheng, Ming-Hua ;

Fouad, Yasser ;

Chan, Wah-Kheong ;

Mendez-Sanchez, Nahum ;

Ahn, Sang Hoon ;

Castera, Laurent ;

Bugianesi, Elisabetta ;

Ratziu, Vlad ;

George, Jacob .

JOURNAL OF HEPATOLOGY, 2020, 73 (01) :202-209

[10] Redefining non-alcoholic fatty liver disease: what's in a name? [J].

不详 .

LANCET GASTROENTEROLOGY & HEPATOLOGY, 2020, 5 (05) :419-419

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