Facile synthesis of folic acid-conjugated fluorapatite nanocrystals for targeted cancer cell fluorescence imaging

被引：6

作者：

Xu, Jun ^{[1
,2
]}

Shen, Xiaoke ^{[1
]}

Jia, Lei ^{[1
,2
]}

Xu, Zhouqing ^{[1
]}

Zhou, Tao ^{[1
]}

Li, Xiaohui ^{[1
]}

Ma, Tieliang ^{[2
]}

Li, Huijun ^{[1
]}

Wang, Yuan ^{[1
]}

Zhu, Taofeng ^{[3
]}

机构：

[1] Henan Polytech Univ, Coll Chem & Chem Engn, Jiaozuo 454000, Peoples R China

[2] Collaborat Innovat Ctr Coal Work Safety, 2001 Shiji Rd, Jiaozuo 454000, Henan, Peoples R China

[3] Jiangsu Univ, Affiliated Yixing Hosp, Yixing, Jiangsu, Peoples R China

来源：

MATERIALS LETTERS | 2017年 / 203卷

基金：

中国国家自然科学基金;

关键词：

Biomaterials; Functional; Luminescence; Nanocomposites; Sensors; FOLATE-RECEPTOR; QUANTUM DOTS; PRECIPITATION; NANOPARTICLES;

D O I：

10.1016/j.matlet.2017.05.102

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Bioluminescent calcium fluorapatite nanocrystals (TCaFAp: Eu) with controlled morphology were fabricated through an easy one-step method and found to have excellent water dispersibility and biocompatibility. Further modification of conjugation with both optical imaging and cell targeting capabilities provided useful nanoprobes for highly sensitive biorecognition applications, which was realized by grafting folic acid onto the surface of TCaFAp: Eu. The uptake of designed TCaFAp: Eu-FA by HepG2 cancer cells was verified by confocal laser scanning microscopy after 30 min, whereas the uptake of TCaFAp: Eu-FA by MCF-7 cells did not work, indicating that the prepared nanoprobe effectively targeted the imaging of cancer cells with over-expression of folate receptor. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：37 / 41

页数：5

共 18 条

[1] Preparation and Physicochemical Characteristics of Luminescent Apatite-Based Colloids [J].

Al-Kattan, Ahmed ;

Dufour, Pascal ;

Dexpert-Ghys, Jeannette ;

Drouet, Christophe .

JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (07) :2918-2924

[2] Photoluminescence Properties of Graphene versus Other Carbon Nanomaterials [J].

Cao, Li ;

Meziani, Mohammed J. ;

Sahu, Sushant ;

Sun, Ya-Ping .

ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (01) :171-180

[3] Preparation and identification of multifunctional mesoporous silica nanoparticles for in vitro and in vivo dual-mode imaging, theranostics, and targeted tracking [J].

Chan, Ming-Hsien ;

Lin, Hsiu-Mei .

BIOMATERIALS, 2015, 46 :149-158

[4] Synthesis of fluorapatite nanorods and nanowires by direct precipitation from solution [J].

Chen, Haifeng ;

Sun, Kai ;

Tang, Zhiyong ;

Law, Robert V. ;

Mansfield, John F. ;

Czajka-Jakubowska, Agata ;

Clarkson, Brian H. .

CRYSTAL GROWTH & DESIGN, 2006, 6 (06) :1504-1508

[5] Effect of OH- on the luminescent efficiency and lifetime of Tb3+ doped yttrium orthophosphate synthesized by solution precipitation [J].

Di, WH ;

Wang, XJ ;

Chen, BJ ;

Lu, SZ ;

Zhao, XX .

JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (27) :13154-13158

[6] Distinguishing Folate-Receptor-Positive Cells from Folate-Receptor-Negative Cells Using a Fluorescence Off-On Nanoprobe [J].

Feng, Duan ;

Song, Yanchao ;

Shi, Wen ;

Li, Xiaohua ;

Ma, Huimin .

ANALYTICAL CHEMISTRY, 2013, 85 (13) :6530-6535

[7] Molecular profiling of single cells and tissue specimens with quantum dots [J].

Gao, XH ;

Nie, SM .

TRENDS IN BIOTECHNOLOGY, 2003, 21 (09) :371-373

[8] New method to prepare very stable and biocompatible fluorescent silica nanoparticles [J].

Ha, Shin-Woo ;

Camalier, Corinne E. ;

Beck, George R., Jr. ;

Lee, Jin-Kyu .

CHEMICAL COMMUNICATIONS, 2009, (20) :2881-2883

[9] Non-covalent decoration of carbon dots with folic acid via a polymer-assisted strategy for fast and targeted cancer cell fluorescence imaging [J].

Lei, Dan ;

Yang, Wen ;

Gong, Yunqian ;

Jing, Jing ;

Nie, Hailiang ;

Yu, Bin ;

Zhang, Xiaoling .

SENSORS AND ACTUATORS B-CHEMICAL, 2016, 230 :714-720

[10] Fabrication of folic acid-sensitive gold nanoclusters for turn-on fluorescent imaging of overexpression of folate receptor in tumor cells [J].

Li, Hongchang ;

Cheng, Yuqing ;

Liu, Yong ;

Chen, Bo .

TALANTA, 2016, 158 :118-124

← 1 2 →