Integrated MEMS structures and CMOS circuits for bioelectronic interface with single cells

被引：0

作者：

Reeves, N ^{[1
]}

Liu, Y ^{[1
]}

Nelson, NM ^{[1
]}

Malhotra, S ^{[1
]}

Loganathan, M ^{[1
]}

Lauenstein, JM ^{[1
]}

Chaiyupatumpa, J ^{[1
]}

Smela, E ^{[1
]}

Abshire, PA ^{[1
]}

机构：

[1] Univ Maryland, College Pk, MD 20742 USA

来源：

2004 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS, VOL 3, PROCEEDINGS | 2004年

关键词：

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We describe a bioMEMS system for confining and electrically inter-facing to single cells for long-term studies. The system comprises microvials that can be covered and uncovered by lids actuated by polypyrrole/gold hinges. Within each vial are integrated bio-amplifiers and/or other sensing circuits to form a biolab-on-a-chip. We have developed a process sequence for fabricating lidded microvials with actuated lids on CMOS die. Initial testing of these "cell clinics" with bovine aortic smooth muscle cells yields successful sensing of the extracellular action potentials from bovine aortic smooth muscle cells using a custom VLSI bioamplifier.

引用

页码：673 / 676

页数：4

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