Is There a Role for the Non-Helicobacter pylori Bacteria in the Risk of Developing Gastric Cancer?

被引：25

作者：

Li, Jackie ^{[1
]}

Perez, Guillermo I. Perez ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Med, New York, NY 10016 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 05期

关键词：

H; pylori; gastric microbiota; gastric cancer; pro-inflammation; MONGOLIAN GERBILS; INFECTION; CARCINOGENESIS; MICROBIOTA; CARCINOMA; DISEASE; COLONIZATION; PATHOLOGY; TRENDS; ADULTS;

D O I：

10.3390/ijms19051353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori is the most abundant bacterium in the gastric epithelium, and its presence has been associated with the risk of developing gastric cancer. As of 15 years ago, no other bacteria were associated with gastric epithelial colonization; but thanks to new methodologies, many other non-H. pylori bacteria have been identified. It is possible that non-H. pylori may have a significant role in the development of gastric cancer. Here, we discuss the specific role of H. pylori as a potential trigger for events that may be conducive to gastric cancer, and consider whether or not the rest of the gastric microbiota represent an additional risk in the development of this disease.

引用

页数：9

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