Reappraising hyalinizing clear cell carcinoma: A population-based study with molecular confirmation

被引:24
作者
Hernandez-Prera, Juan C. [1 ]
Kwan, Ricky [1 ]
Tripodi, Joseph [1 ]
Chiosea, Simion [2 ]
Cordon-Cardo, Carlos [1 ]
Najfeld, Vesna [1 ]
Demicco, Elizabeth G. [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA
[2] Univ Pittsburgh Med Ctr, Dept Pathol, Pittsburgh, PA USA
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 03期
关键词
EWSR1; clear cell carcinoma; hyalinizing clear cell carcinoma; salivary gland; MINOR SALIVARY-GLAND; OF-THE-LITERATURE; GLYCOGEN-RICH ADENOCARCINOMA; PAROTID-GLAND; MYOEPITHELIAL CARCINOMA; DIFFERENTIAL-DIAGNOSIS; EWSR1; REARRANGEMENTS; CASE SERIES; TONGUE; TUMORS;
D O I
10.1002/hed.24637
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as it was for many years considered a diagnosis of exclusion. Methods. All available salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. Literature review was performed. Results. We found 15 patients with HCCCs (10 women, 5 men), 13 with EWSR1 rearrangement. Median age at diagnosis was 57 years (range, 31-87 years). Oral cavity (n = 9) and base of tongue (n = 4) were the most frequent primary sites. Combining our cases with those identified in literature review, the 10-year risk of local recurrence and locoregional nodal metastasis were 49% and 15%, respectively. Conclusion. Molecularly confirmed HCCC accounted for 2.5% of salivary gland malignancies at our institution. HCCCs are indolent tumors with a propensity for locoregional recurrence. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码:503 / 511
页数:9
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