Adipose Tissue and Atherosclerosis

被引：14
|
作者：
Poledne, R. [1 ]
Lesna, I. Kralova [1 ]
Cejkova, S. [1 ]
机构：
[1] Inst Clin & Expt Med, Ctr Med Expt, Lab Atherosclerosis Res, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2015年 / 64卷
关键词：
Adipose tissue; Dyslipidemia; Inflammation; Macrophages; INSULIN-RESISTANCE; MACROPHAGE; FAT; OBESITY; LEPTIN; ACTIVATION; MONOCYTES; CELLS; LIVER; ACCUMULATION;
D O I：
10.33549/physiolres.933152
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
High-energy intake which exceeds energy expenditure leads to the accumulation of triglycerides in adipose tissue, predominantly in large-size adipocytes. This metabolic shift, which drives the liver to produce atherogenic dyslipidemia, is well documented. In addition, an increasing amount of monocytes/macrophages, predominantly the proinflammatory M1-type, cumulates in ectopic adipose tissue. The mechanism of this process, the turnover of macrophages in adipose tissue and their direct atherogenic effects all remain to be analyzed.
引用
收藏
页码：S395 / S402
页数：8
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