Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation

被引：41

作者：

Lin, Yung-Kuo ^{[1
,2
]}

Chen, Yi-Ann ^{[5
]}

Lee, Ting-I ^{[3
]}

Chen, Yao-Chang ^{[6
]}

Chen, Shih-Ann ^{[7
,8
]}

Chen, Yi-Jen ^{[1
,4
]}

机构：

[1] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Cardiovasc Med, Taipei, Taiwan

[2] Taipei Med Univ, Coll Med, Dept Internal Med, Div Cardiol,Sch Med, Taipei, Taiwan

[3] Taipei Med Univ, Wan Fang Hosp, Div Endocrinol & Metab, Taipei, Taiwan

[4] Taipei Med Univ, Coll Med, Grad Inst Clin Med, 111 Hsin Lung Rd,Sec 3, Taipei 116, Taiwan

[5] Sijhih Cathay Gen Hosp, Div Nephrol, New Taipei, Taiwan

[6] Natl Def Med Ctr, Dept Biomed Engn, Taipei, Taiwan

[7] Vet Gen Hosp Taipei, Div Cardiol, Taipei, Taiwan

[8] Vet Gen Hosp Taipei, Cardiovasc Res Ctr, Taipei, Taiwan

来源：

CIRCULATION JOURNAL | 2018年 / 82卷 / 05期

关键词：

Aging; Atria; Atrial fibrillation; Pulmonary veins; PULMONARY VEIN ARRHYTHMOGENESIS; SINOATRIAL NODE; HEART-FAILURE; RAT MODEL; VENTRICULAR-TACHYCARDIA; CALCIUM HOMEOSTASIS; OXIDATIVE STRESS; NITRIC-OXIDE; AGE; SEX;

D O I：

10.1253/circj.CJ-17-0242

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

引用

页码：1237 / 1244

页数：8

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