Recent Advances in Stetter Reaction and Related Chemistry: An update

被引：51

作者：

Heravi, Majid M. ^{[1
]}

Zadsirjan, Vahideh ^{[1
]}

Kafshdarzadeh, Kosar ^{[1
]}

Amiri, Zahra ^{[1
]}

机构：

[1] Alzahra Univ, Dept Chem, Sch Sci, Tehran, Iran

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 12期

基金：

美国国家科学基金会;

关键词：

Stetter Reaction; Total synthesis; heterocycles; Asymmetric Stetter reaction; Stetter-like reaction; N-HETEROCYCLIC CARBENES; ACTIVATED DOUBLE-BONDS; STEREOCONTROLLED TOTAL-SYNTHESIS; CATALYZED BENZOIN CONDENSATION; FRIEDEL-CRAFTS REACTIONS; NATURAL-PRODUCTS; ENANTIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; GENERAL STRATEGY; FORMAL SYNTHESIS;

D O I：

10.1002/ajoc.202000378

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Stetter reaction is actually a special C-C bond forming reaction through a 1,4-addition reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes and Michael acceptors catalyzed by N-heterocyclic carbenes (NHC's) leading to preparation of 1,4-dicarbonyl compounds via carbon-carbon bond formation. It offers a powerful approach to access 1,4-dicarbonyl compounds which are significant starting materials and intermediates in the synthesis of several heterocyclic systems, and bioactive heterocyclic framework which are present in natural products. In this review we try to underscore the recent advances in Stetter reaction and its applications from 2015 till date. Notably, we focused on the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products, which have largely been overlooked, previously.

引用

页码：1999 / 2034

页数：36