A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines

被引：6

作者：

Yu, Chang-Bin ^{[1
]}

Li, Xiang ^{[1
]}

Zhou, Yong-Gui ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 07期

基金：

中国国家自然科学基金;

关键词：

palladium; asymmetric hydrogenation; tandem reactions; indoles; 2; 3-disubstituted indolines; CATALYZED ASYMMETRIC HYDROGENATION; KINETIC RESOLUTION; TANDEM; INDOLES; CYCLOADDITIONS; HETEROCYCLES; ALKALOIDS; DIVERGENT; ACCESS;

D O I：

10.1002/ajoc.201900289

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A divergent and enantioselective procedure for synthesis of 2,3-disubstituted indolines was developed through Bronsted acid/palladium-complex promoted condensation/reductive alkylation/ hydrogenation cascade reactions from simple amino ketones and aldehydes in one operation. Five Bronsted acid-promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process. This strategy provides facile synthesis of structurally diverse multi-substituted chiral indolines.

引用

页码：1118 / 1121

页数：4

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