A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines

被引：6
|
作者：
Yu, Chang-Bin [1 ]
Li, Xiang [1 ]
Zhou, Yong-Gui [1 ,2 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 07期
基金：
中国国家自然科学基金;
关键词：
palladium; asymmetric hydrogenation; tandem reactions; indoles; 2; 3-disubstituted indolines; CATALYZED ASYMMETRIC HYDROGENATION; KINETIC RESOLUTION; TANDEM; INDOLES; CYCLOADDITIONS; HETEROCYCLES; ALKALOIDS; DIVERGENT; ACCESS;
D O I：
10.1002/ajoc.201900289
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A divergent and enantioselective procedure for synthesis of 2,3-disubstituted indolines was developed through Bronsted acid/palladium-complex promoted condensation/reductive alkylation/ hydrogenation cascade reactions from simple amino ketones and aldehydes in one operation. Five Bronsted acid-promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process. This strategy provides facile synthesis of structurally diverse multi-substituted chiral indolines.
引用
收藏
页码：1118 / 1121
页数：4
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