Novel computational and experimental approaches for investigating the thermodynamics of metabolic networks

被引：10
|
作者：
Khana, Daven B. [1 ,2 ,4 ]
Callaghan, Melanie M. [1 ,3 ]
Amador-Noguez, Daniel [1 ,2 ,3 ]
机构：
[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA
[2] Univ Wisconsin, Great Lakes Bioenergy Res Ctr, Madison, WI 53706 USA
[3] Oak Ridge Natl Lab, Ctr Bioenergy Innovat, Oak Ridge, TN 37830 USA
[4] Univ Wisconsin, Microbiol Doctoral Training Program, Madison, WI USA
来源：
CURRENT OPINION IN MICROBIOLOGY | 2022年 / 66卷
基金：
美国国家科学基金会;
关键词：
ELEMENTARY FLUX MODES; ESCHERICHIA-COLI; STRATEGY; INSIGHTS; DEFINES; LEVEL; TOOLS; NMR;
D O I：
10.1016/j.mib.2021.11.007
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Thermodynamic analysis of metabolic networks has emerged as a useful new tool for pathway design and metabolic engineering. Understanding the relationship between the thermodynamic driving force of biochemical reactions and metabolic flux has generated new insights regarding the design principles of microbial carbon metabolism. This review summarizes the various lessons that can be obtained from the thermodynamic analysis of metabolic pathways, illustrates concepts of computational thermodynamic tools, and highlights recent applications of thermodynamic analysis to pathway design in industrially relevant microbes.
引用
收藏
页码：21 / 31
页数：11
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