Synergistic Combinations of the CCR5 Inhibitor VCH-286 with Other Classes of HIV-1 Inhibitors

被引：6

作者：

Asin-Milan, Odalis ^{[1
,2
]}

Sylla, Mohamed ^{[1
]}

El-Far, Mohamed ^{[1
]}

Belanger-Jasmin, Genevieve ^{[1
]}

Haidara, Alpha ^{[1
]}

Blackburn, Julie ^{[1
]}

Chamberland, Annie ^{[1
]}

Tremblay, Cecile L. ^{[1
,2
,3
]}

机构：

[1] Univ Montreal, Ctr Hosp, Ctr Rech, Montreal, PQ, Canada

[2] Univ Montreal, Fac Med, Dept Microbiol & Immunol, Montreal, PQ, Canada

[3] Inst Natl Sante Publ Quebec, Lab Sante Publ Quebec, Montreal, PQ, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 12期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; SMALL-MOLECULE INHIBITOR; ENTRY INHIBITORS; POTENT; INFECTION; MARAVIROC; INDIVIDUALS; PROGRESSION; ANTAGONISTS; VICRIVIROC;

D O I：

10.1128/AAC.03630-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we evaluated the in vitro anti-HIV-1 activity of the experimental CCR5 inhibitor VCH-286 as a single agent or in combination with various classes of HIV-1 inhibitors. Although VCH-286 used alone had highly inhibitory activity, paired combinations with different drug classes led to synergistic or additive interactions. However, combinations with other CCR5 inhibitors led to effects ranging from synergy to antagonism. We suggest that caution should be exercised when combining CCR5 inhibitors in vivo.

引用

页码：7565 / 7569

页数：5

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