The effect of the herbal medicine dai-kenchu-to on post-operative ileus

被引：88
作者：
Itoh, T
Yamakawa, I
Mai, M
Yamaguchi, N
Kanda, T
机构：
[1] Kanazawa Med Univ, Dept Gen Med, Kahokugunn, Ishikawa 9200293, Japan
[2] Kanazawa Univ, Canc Res Inst, Div Mol Diagnost Pathol, Kanazawa, Ishikawa, Japan
[3] Kanazawa Med Univ, Dept Serol & Immunol, Kahokugunn, Ishikawa 9200293, Japan
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2002年 / 30卷 / 04期
关键词：
dai-kenchu-to; herbal medicine; post-operative ileus;
D O I：
10.1177/147323000203000410
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Post-operative ileus (PI) is an inevitable adverse consequence of abdominal surgical procedures. We performed a randomized study of the effects of the herbal medicine dai-kenchu-to (DKT) on 24 patients with PI. Patients received either 15 g of oral DKT or placebo daily for 14 days. The effects on upper gastrointestinal motility, frequency of secondary operation and recurrence of PI were investigated. The frequency of surgical operation was significantly lower in patients receiving DKT compared with placebo. Oral administration of DKT was clinically effective for PI in reducing both the need for further surgery and the recurrence of PI.
引用
收藏
页码：428 / 432
页数：5
相关论文
共 19 条
[1]   A prospective, randomized, double blinded, placebo controlled trial of cisapride after colorectal surgery [J].
Brown, TA ;
McDonald, J ;
Williard, W .
AMERICAN JOURNAL OF SURGERY, 1999, 177 (05) :399-401
[2]   Prokinetic agents for the treatment of postoperative ileus in adults: A review of the literature [J].
Bungard, TJ ;
Kale-Pradhan, PB .
PHARMACOTHERAPY, 1999, 19 (04) :416-423
[3]   The effect of cisapride on the corrected QT interval and QT dispersion in premature infants [J].
Cools, F ;
Benatar, A ;
Bougatef, A ;
Vandenplas, Y .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2001, 33 (02) :178-181
[4]   Pathophysiology of adynamic ileus [J].
Cullen, JJ ;
Caropreso, DK ;
Hemann, LL ;
Hinkhouse, M ;
Conklin, JL ;
Ephgrave, KS .
DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (04) :731-737
[5]  
HALTE K, 2000, BRIT J SURG, V87, P1480
[6]  
Hayakawa Terumasa, 1999, Journal of Smooth Muscle Research, V35, P55
[7]   Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs [J].
Jin, XL ;
Shibata, C ;
Naito, H ;
Ueno, T ;
Funayama, Y ;
Fukushima, K ;
Matsuno, S ;
Sasaki, I .
DIGESTIVE DISEASES AND SCIENCES, 2001, 46 (06) :1171-1176
[8]   Review of postoperative ileus [J].
Kehlet, H ;
Holte, K .
AMERICAN JOURNAL OF SURGERY, 2001, 182 (5A) :3S-10S
[9]   PACAP-(6-38) inhibits the effects of vasoactive intestinal polypeptide, but not PACAP, on the small intestinal circular muscle [J].
Lázár, LA ;
Shahbazian, A ;
Benkó, R ;
Tóth, G ;
Penke, B ;
Barthó, L ;
Holzer, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 431 (02) :259-264
[10]   Peritoneal adhesions: Etiology, pathophysiology, and clinical significance - Recent advances in prevention and management [J].
Liakakos, T ;
Thomakos, N ;
Fine, PM ;
Dervenis, C ;
Young, RL .
DIGESTIVE SURGERY, 2001, 18 (04) :260-273
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