The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome

被引:17
作者
Lai, Chih-Cheng [1 ]
Sung, Mei-I. [2 ]
Ho, Chung-Han [3 ,4 ]
Liu, Hsiao-Hua [2 ]
Chen, Chin-Ming [4 ,5 ]
Chiang, Shyh-Ren [2 ,4 ]
Chao, Chien-Ming [1 ]
Liu, Wei-Lun [1 ]
Hsing, Shu-Chen [2 ]
Cheng, Kuo-Chen [2 ,6 ]
机构
[1] Chi Mei Med Ctr, Dept Intens Care Med, Liouying, Taiwan
[2] Chi Mei Med Ctr, Dept Internal Med, Tainan, Taiwan
[3] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan
[4] Chia Nan Univ Pharm & Sci, Tainan, Taiwan
[5] Chi Mei Med Ctr, Dept Intens Care Med, Tainan, Taiwan
[6] Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn, Tainan, Taiwan
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
BERLIN DEFINITION; LUNG INJURY; OUTCOMES; FAILURE; SEVERITY; UTILITY; ARDS;
D O I
10.1038/srep44784
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality.
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页数:6
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